Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ever alert for inflammation

03.05.2010
Regulatory T cells can travel to and from the skin while controlling immune responses in that organ

By showing that anti-inflammatory regulatory T cells (Tregs) move to and from the skin whilst regulating an immune response, an international research team involving RIKEN researchers has provided insight into how immune cells behave during inflammation.

The team, including Michio Tomura, Shohei Hori and Osami Kanagawa from the RIKEN Research Center for Allergy and Immunology in Yokohama and Kenji Kabashima from the Kyoto University Graduate School of Medicine, used a specially engineered line of mice to track immune cells in a living animal model. The mice—developed previously by Tomura, Kanagawa and colleagues—express a protein called Kaede that usually causes their cells to glow green, but glow red once exposed to violet light. This color switching allowed the researchers to tag cells from one part of the body and track them as they moved elsewhere. “This kind of approach is only possible in our original Kaede mouse system and by collaboration among research centers within RIKEN,” says Tomura.

Tracking the tagged cells revealed that T cells traveled from the skin to a nearby lymph node in the absence of any immune stimulus, suggesting to the researchers that immune cells migrate through non-inflamed tissues as part of their surveillance function in the body.

When the researchers painted an antigen on the skin of these mice to induce an immune response, they observed an increase in the proportion of T cells in the nearby lymph node that had come from the skin. In mice with depleted immunosuppressive Tregs, they recorded an increase in skin swelling after antigen exposure. The team therefore believes that Tregs are required to reduce inflammation within the skin.

In tissue culture experiments, Tomura, Kabashima and colleagues found that the Tregs sourced from inflamed skin suppressed the proliferation of immune cells from the lymph node, better than Tregs that had not come from skin. The researchers suggest that was probably because skin Tregs expressed higher levels of anti-inflammatory molecules.

When they injected Tregs from inflamed skin of one mouse into inflamed skin of other mice, those Tregs reduced swelling better than cells from non-inflamed skin. The researchers also observed Tregs moving to newly inflamed areas of skin from other areas.

Since Tregs can travel to and from the skin while controlling immune responses in that organ, the researchers suggest that enhancing Treg migration or function could therefore be a promising therapeutic approach to dampen inflammation in various organs.

The corresponding author for this highlight is based at the Laboratory for Autoimmune Regulation, RIKEN Research Center for Allergy and Immunology

Journal information

1. Tomura, M., Honda, T., Tanizaki, H., Otsuka, A., Egawa, G., Tokura, Y. Waldmann, H., Hori, S., Cyster, J.G., Watanabe, T., Miyachi, Y., Kanagawa, O. & Kabashima, K. Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. The Journal of Clinical Investigation 120, 883–893 (2010)

gro-pr | Research asia research news
Further information:
http://www.rikenresearch.riken.jp/eng/research/6251
http://www.researchsea.com

More articles from Life Sciences:

nachricht Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden

nachricht The pyrenoid is a carbon-fixing liquid droplet
22.09.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>