Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Ever alert for inflammation

Regulatory T cells can travel to and from the skin while controlling immune responses in that organ

By showing that anti-inflammatory regulatory T cells (Tregs) move to and from the skin whilst regulating an immune response, an international research team involving RIKEN researchers has provided insight into how immune cells behave during inflammation.

The team, including Michio Tomura, Shohei Hori and Osami Kanagawa from the RIKEN Research Center for Allergy and Immunology in Yokohama and Kenji Kabashima from the Kyoto University Graduate School of Medicine, used a specially engineered line of mice to track immune cells in a living animal model. The mice—developed previously by Tomura, Kanagawa and colleagues—express a protein called Kaede that usually causes their cells to glow green, but glow red once exposed to violet light. This color switching allowed the researchers to tag cells from one part of the body and track them as they moved elsewhere. “This kind of approach is only possible in our original Kaede mouse system and by collaboration among research centers within RIKEN,” says Tomura.

Tracking the tagged cells revealed that T cells traveled from the skin to a nearby lymph node in the absence of any immune stimulus, suggesting to the researchers that immune cells migrate through non-inflamed tissues as part of their surveillance function in the body.

When the researchers painted an antigen on the skin of these mice to induce an immune response, they observed an increase in the proportion of T cells in the nearby lymph node that had come from the skin. In mice with depleted immunosuppressive Tregs, they recorded an increase in skin swelling after antigen exposure. The team therefore believes that Tregs are required to reduce inflammation within the skin.

In tissue culture experiments, Tomura, Kabashima and colleagues found that the Tregs sourced from inflamed skin suppressed the proliferation of immune cells from the lymph node, better than Tregs that had not come from skin. The researchers suggest that was probably because skin Tregs expressed higher levels of anti-inflammatory molecules.

When they injected Tregs from inflamed skin of one mouse into inflamed skin of other mice, those Tregs reduced swelling better than cells from non-inflamed skin. The researchers also observed Tregs moving to newly inflamed areas of skin from other areas.

Since Tregs can travel to and from the skin while controlling immune responses in that organ, the researchers suggest that enhancing Treg migration or function could therefore be a promising therapeutic approach to dampen inflammation in various organs.

The corresponding author for this highlight is based at the Laboratory for Autoimmune Regulation, RIKEN Research Center for Allergy and Immunology

Journal information

1. Tomura, M., Honda, T., Tanizaki, H., Otsuka, A., Egawa, G., Tokura, Y. Waldmann, H., Hori, S., Cyster, J.G., Watanabe, T., Miyachi, Y., Kanagawa, O. & Kabashima, K. Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. The Journal of Clinical Investigation 120, 883–893 (2010)

gro-pr | Research asia research news
Further information:

More articles from Life Sciences:

nachricht Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute

nachricht 'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

'Neighbor maps' reveal the genome's 3-D shape

27.10.2016 | Life Sciences

Gene therapy shows promise for treating Niemann-Pick disease type C1

27.10.2016 | Life Sciences

Solid progress in carbon capture

27.10.2016 | Power and Electrical Engineering

More VideoLinks >>>