Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aging Stem Cells: New Study Sheds Light on Senescence Process

25.01.2010
Researchers have found that MECP2, a gene that modifies the chromatin in the cell, has an important role in stem cell aging.

Throughout adulthood, stem cells work to replace mature cells lost to turnover, injury or disease. Some of the genes responsible for keeping stem cells active and productive modify the chromatin, the complex combination of DNA and fibers that make up chromosomes.

Researchers from the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and the Human Health Foundation in Spoleto, Italy studied the impact of MECP2, one of the chromatin modifier genes whose mutations underlie RETT syndrome, a severe X-linked neurodevelopmental disorder, on mesenchymal stem cells, or MSCs, multipotent stem cells that can differentiate into a variety of cell types. Their findings were published in the Journal of the Federation of American Societies for Experimental Biology.

“Our studies suggest that MECP2 is a factor whose expression must be tightly regulated to avoid alteration in the cell’s function,” said Dr. Umberto Galderisi, Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Italy and lead author of the study. “To be specific, its inhibition induces the senescence, or the aging, phenomena in MSCs.”

MSC’s are of particular interest to researchers, because of the multiple roles that they perform. They support hematopoiesis, or blood production, and contribute to the maintenance of many organs and tissues. Their aging has profound consequences on body physiology.

“Studies on in vitro stem cell senescence can be of interest in order to dissect molecular events leading to a decline of stem cell functions with advancing of age,” said Dr. Antonio Giordano, director of the Sbarro Institute and the Center for Biotechnology at Temple University in Philadelphia, PA.

Sbarro Health Research Organization (www.shro.org) funds the Sbarro Institute for Cancer Research and Molecular Medicine, a leading nonprofit research center for cancer, diabetes, and cardiovascular disease. Based in Philadelphia, Pennsylvania on the campus of Temple University, our programs train young scientists from around the globe.

The Human Health Foundation is a nonprofit research foundation devoted to basic medical research and biotechnology located in Spoleto, Italy.

Ilene Rush | Newswise Science News
Further information:
http://www.shro.org

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>