Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The new age of proteomics: An integrative vision of the cellular world

18.01.2013
The head of CNIO's Proteomics Core Unit, Javier Munoz, working alongside Dutch researchers, revises the technology of the post-genomic age and its contributions to the advance of biomedicine

The enormous complexity of biological processes requires the use of high­performance technologies —also known as '­omics'—, that are capable of carrying out complete integrated analyses of the thousands of molecules that cells are made up of, and of studying their role in illnesses.

In the post-genomic age we find ourselves in, the comprehensive study of cellular proteins —prote-omics— acquires a new dimension, as proteins are the molecular executors of genes and, therefore, the most important pieces of the puzzle if we wish to understand more completely how cells work.

The head of the Proteomics Core Unit at the Spanish National Cancer Research Centre (CNIO), Javier Muñoz, publishes this week, alongside researchers from the University of Utrecht and the Netherlands Proteomics Centre, a revision of the latest technological advances in proteomics including improvements in the preparation of biological samples, in mass spectrometry techniques and in the bioinformatic analysis of data. The article has been published this week in the journal Nature Review Genetics.

To illustrate these advances, the authors coin the term "next-­‐generation proteomics", in reference to the new genome sequencing techniques employed by most of the scientific community. They use the example of several illustrative proteomic study cases that have brought to light key data in several biomedical research scenarios.

The authors end their revision by emphasising the main applications of these studies for clinical practice, such as the search for useful new biomarkers to improve cancer diagnosis and prognosis, or the design of personalized therapies for patients following the analysis of a reduced number of cells.

About Javier Muñoz

Javier Muñoz joined CNIO in October 2012 to lead the centre's Proteomics Core Unit. Muñoz, who joined us from the Albert Heck laboratory in Holland, is an expert in the multidisciplinary study of cancer, and focuses his CNIO research on the study of the proteome and its regulation in processes that determine cellular identity and plasticity.

Nuria Noriega | EurekAlert!
Further information:
http://www.cnio.es

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>