Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Adapting personal glucose monitors to detect DNA

01.03.2012
An inexpensive device used by millions of people with diabetes could be adapted into a home DNA detector that enables individuals to perform home tests for viruses and bacteria in human body fluids, in food and in other substances, scientists are reporting in a new study.

The report on this adaptation of the ubiquitous personal glucose monitor, typically used to test blood sugar levels, appears in ACS' journal Analytical Chemistry.

Yi Lu and Yu Xiang point out that developing low-cost tests for the public to use for early diagnosis of diseases, checking the safety of food and other testing that now take days and sophisticated laboratory instruments is one of the greatest challenges in chemistry.

Such tests could improve health and reduce costs, especially for people in developing countries or rural areas in developed countries with scant medical resources. Lu and Xiang have been responding to this challenge with adaptations to the home glucose monitor, an essential device for millions of people with diabetes that's inexpensive and simple to use.

In their latest research, the scientists describe how they adapted a glucose meter to monitor DNA. Their test takes place in a liquid containing sucrose (a sugar that isn't detected by glucose meters). First, a bacterial or viral DNA fragment is captured and concentrated on beads.

Then, the researchers add an enzyme that is stuck to a different DNA (which can bind to the bacterial or viral DNA). The enzyme, called invertase, turns the sucrose into glucose, which the glucose meter can measure. They detected a hepatitis B virus DNA fragment at concentrations comparable to or in some cases even better than many current DNA measurement systems, which are much more expensive and time-consuming.

The authors acknowledge funding from the U.S. Department of Energy, the National Institutes of Health and the National Science Foundation.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society contact newsroom@acs.org

Michael Bernstein | EurekAlert!
Further information:
http://www.acs.org

Further reports about: Adapting DNA fragment Xiang chemical engineering viral DNA

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>