Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy
Chemotherapy is still the backbone of today’s cancer treatment. This is exemplified by acute myeloid leukemia (AML), a disease which is responsive to intense chemotherapy based treatment regimens, which are at least curative in a fraction of patients. Anthracyclines belong to the key chemotherapeutic drugs applied worldwide in the treatment of AML.
Unfortunately, the administration dose of anthracyclines is limited by their cardiotoxicity and the development of drug-resistance of tumors. In addition, the efficiency of anthracyclines decreases during circulation in the blood stream due to its rapid metabolicdegradation.
To improve the pharmacological properties of anthracyclines, a novel nanomedicine drug delivery system has been developed by the groups of Prof. Dr. Tanja Weil (Institute of Organic Chemistry/Macromolecular Chemistry, Ulm University) and Prof. Dr. Christian Buske (Comprehensive Cancer Center Ulm, Institute of Experimental Cancer Research, University Hospital Ulm).
This biopolymer carries multiple copies of an anti-tumor drug molecule, it shows high stability in serum and efficient release in tumor cells by a dual mechanism. Significantly higher survival rates have been observed in an ex vivo animal model suggesting its potential for designing next generation anti-leukemia treatments. The results have been published in the Journal of Advanced Healthcare Materials.
Yuzhou Wu, Susann Ihme, Michaela Feuring-Buske, Seah Ling Kuan, Klaus Eisele, Markus Lamla, Yanran Wang, Christian Buske, and Tanja Weil. A core-shell albumin copolymer nanotransporter for high capacity loading and two-step release of doxorubicin with enhanced anti-leukemia activity. Advanced Healthcare Materials. http://doi.wiley.com/10.1002/adhm.201200296.”
Prof. Dr. Tanja Weil, Tel.: 0049/731 50-22871 or 0049/731 50-22870
Prof. Dr. Christian Buske, Tel.: 0049/731 500-65800
PD Dr. Michaela Feuring-Buske, Tel.: 0049/731 500-65823
Willi Baur | idw
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...