The study is the first to use high-throughput sequencing to uncover active genes in developing brains, and it is likely the best evidence thus far for the activity in the brain of such a large number of genes.
Some of the genes that the researchers found in mice are known to be matched to the human genes that are involved in neurological disorders, such as Alzheimer's disease, autism, and some forms of mental retardation. "Our results can help to pinpoint the specific time during brain development when the genes related to certain diseases are active," said Ma. "This knowledge may help other scientists to develop drugs or gene therapies that can treat the diseases. For example, if a particular gene defect causes poorly constructed connections between certain neurons, a drug might be developed that enhances those connections to compensate for the gene defect."
Ma said his future research plans include looking at some of the genes to see whether they are important for the brain to be formed properly. Chen plans to investigate, specifically, how genes function in development disorders of the brain. This research was supported by Penn State, the National Institutes of Health, and the National Science Foundation.
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Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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