A large international research group led by Dr. Tarik Möröy, a researcher at the Institut de recherches cliniques de Montréal (IRCM), has discovered that a variant of the gene "Growth Factor Independence 1" (GFI1) predisposes humans to develop acute myeloid leukemia (AML), a certain subtype of blood cancer.
This study was coordinated by Dr. Möröy at the IRCM in collaboration with multiple international study groups located throughout Germany, the Netherlands and the United States. This new finding has been prepublished online in Blood, the Journal of the American Society of Hematology. Dr. Cyrus Khandanpour, medical doctor and postdoctoral fellow in Dr. Möröy's group at the IRCM, is the first author of the study.
The study describes and validates the association between a variant form of GFI1 (called GFI136N) and AML in two large patient cohorts (comprising about 1,600 patients from Germany and the Netherlands) and the respective controls. The association between GFI136N and other already established markers in the field of AML was examined in collaboration with several study clinics in Rotterdam, Nijmegen (Netherlands), Dresden, Essen, Munich (Germany), Columbus and City of Hope (USA) showing that GFI136N is a new independent marker for predisposition to AML. "This extensive collaboration effort resulted in one of the largest association studies published in the field of AML," pointed out Dr. Möröy.
The researchers performed different examinations showing that GFI136N behaves differently than its more common form. "A possible explanation for the predisposition to AML this variant leads to," mentioned Dr. Khandanpour, "is that it cannot interact with all the proteins the more common GFI1 usually interacts with. One reason for this is a different localization of this variant within the cell, but different functions of the variant at the molecular level may also account for this behaviour."
Carriers of this variant have a 60% higher risk of developing AML. This study brings new insight on the development of AML and suggests also that GFI136N might be used in the future as a new biomarker for evaluating prognosis in AML patients.
This work was supported in part by a grant from CRS–The Cancer Research Society (Canada) to Dr. Möröy and by the COLE Foundation, which granted a fellowship to Dr. Khandanpour.
References for this article are available at: http://bloodjournal.hematologylibrary.org/papbyrecent.dtl
Blood First Edition Paper, prepublished online January 15, 2010; DOI 10.1182/blood-2009-08-239822
Dr. Tarik Möröy is President and Scientific Director of the IRCM, Full Research Professor IRCM and Director of the Research Unit on Hematopoiesis and Cancer at the IRCM. He is also Full Research Professor in the Department of Microbiology and Immunology and accredited member in the Department of Biochemistry at the Université de Montréal. In addition, he is Adjunct Professor in the Department of Biochemistry and a member of the Division of Experimental Medicine at McGill University. Dr. Möröy holds a Tier 1 Canada Research Chair in Hematopoiesis and Immune Cell Differentiation. Dr. Cyrus Khandanpour is a medical doctor and postdoctoral fellow in Dr. Möröy's laboratory and holder of a COLE Foundation fellowship.
Established in 1967, the IRCM (www.ircm.qc.ca) now has 36 research units specialized in areas as diverse as immunity and viral infections, cardiovascular and metabolic diseases, cancer, neurobiology and development, systems biology and medicinal chemistry, clinical research and bioethics. It has a staff of more than 450 people. The IRCM is an independent institution, affiliated with the Université de Montréal and its clinic is associated to the Centre hospitalier de l'Université de Montréal (CHUM). The IRCM holds a close collaboration with McGill University.
Olivier Lagueux | EurekAlert!
A room with a view - or how cultural differences matter in room size perception
25.04.2017 | Max-Planck-Institut für biologische Kybernetik
Studying a catalyst for blood cancers
25.04.2017 | University of Miami Miller School of Medicine
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Earth Sciences
25.04.2017 | Life Sciences
25.04.2017 | Earth Sciences