Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A variant of the gene GFI1 predisposes to a subtype of blood cancer

19.01.2010
This study on AML was coordinated in Montreal by Dr. Tarik Möröy (IRCM) in collaboration with multiple international study groups

A large international research group led by Dr. Tarik Möröy, a researcher at the Institut de recherches cliniques de Montréal (IRCM), has discovered that a variant of the gene "Growth Factor Independence 1" (GFI1) predisposes humans to develop acute myeloid leukemia (AML), a certain subtype of blood cancer.

This study was coordinated by Dr. Möröy at the IRCM in collaboration with multiple international study groups located throughout Germany, the Netherlands and the United States. This new finding has been prepublished online in Blood, the Journal of the American Society of Hematology. Dr. Cyrus Khandanpour, medical doctor and postdoctoral fellow in Dr. Möröy's group at the IRCM, is the first author of the study.

The study describes and validates the association between a variant form of GFI1 (called GFI136N) and AML in two large patient cohorts (comprising about 1,600 patients from Germany and the Netherlands) and the respective controls. The association between GFI136N and other already established markers in the field of AML was examined in collaboration with several study clinics in Rotterdam, Nijmegen (Netherlands), Dresden, Essen, Munich (Germany), Columbus and City of Hope (USA) showing that GFI136N is a new independent marker for predisposition to AML. "This extensive collaboration effort resulted in one of the largest association studies published in the field of AML," pointed out Dr. Möröy.

The researchers performed different examinations showing that GFI136N behaves differently than its more common form. "A possible explanation for the predisposition to AML this variant leads to," mentioned Dr. Khandanpour, "is that it cannot interact with all the proteins the more common GFI1 usually interacts with. One reason for this is a different localization of this variant within the cell, but different functions of the variant at the molecular level may also account for this behaviour."

Carriers of this variant have a 60% higher risk of developing AML. This study brings new insight on the development of AML and suggests also that GFI136N might be used in the future as a new biomarker for evaluating prognosis in AML patients.

This work was supported in part by a grant from CRS–The Cancer Research Society (Canada) to Dr. Möröy and by the COLE Foundation, which granted a fellowship to Dr. Khandanpour.

References for this article are available at: http://bloodjournal.hematologylibrary.org/papbyrecent.dtl

Blood First Edition Paper, prepublished online January 15, 2010; DOI 10.1182/blood-2009-08-239822

Dr. Tarik Möröy is President and Scientific Director of the IRCM, Full Research Professor IRCM and Director of the Research Unit on Hematopoiesis and Cancer at the IRCM. He is also Full Research Professor in the Department of Microbiology and Immunology and accredited member in the Department of Biochemistry at the Université de Montréal. In addition, he is Adjunct Professor in the Department of Biochemistry and a member of the Division of Experimental Medicine at McGill University. Dr. Möröy holds a Tier 1 Canada Research Chair in Hematopoiesis and Immune Cell Differentiation. Dr. Cyrus Khandanpour is a medical doctor and postdoctoral fellow in Dr. Möröy's laboratory and holder of a COLE Foundation fellowship.

Established in 1967, the IRCM (www.ircm.qc.ca) now has 36 research units specialized in areas as diverse as immunity and viral infections, cardiovascular and metabolic diseases, cancer, neurobiology and development, systems biology and medicinal chemistry, clinical research and bioethics. It has a staff of more than 450 people. The IRCM is an independent institution, affiliated with the Université de Montréal and its clinic is associated to the Centre hospitalier de l'Université de Montréal (CHUM). The IRCM holds a close collaboration with McGill University.

Olivier Lagueux | EurekAlert!
Further information:
http://www.ircm.qc.ca

More articles from Life Sciences:

nachricht Researchers reveal new details on aged brain, Alzheimer's and dementia
21.11.2017 | Allen Institute

nachricht Nanoparticles help with malaria diagnosis – new rapid test in development
21.11.2017 | Fraunhofer-Institut für Silicatforschung ISC

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

From Hannover around the world and to the Mars: LZH delivers laser for ExoMars 2020

21.11.2017 | Physics and Astronomy

Borophene shines alone as 2-D plasmonic material

21.11.2017 | Materials Sciences

Penn study identifies new malaria parasites in wild bonobos

21.11.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>