Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A thirst for excitement is hidden in your genes

06.10.2010
Sensation seeking—the urge to do exciting things—has been linked to dopamine, a chemical that carries messages in your brain. For a new study published in Psychological Science, a journal of the Association for Psychological Science, scientists analyzed genes in the dopamine system and found a group of mutations that help predict whether someone is inclined toward sensation seeking.

Sensation seeking has been linked to a range of behavior disorders, such as drug addiction. It isn't all bad, though. "Not everyone who's high on sensation seeking becomes a drug addict. They may become an Army Ranger or an artist.

It's all in how you channel it," says Jaime Derringer, a PhD student at the University of Minnesota and the first author of the study. She wanted to use a new technique to find out more about the genetics of sensation seeking.

Most obvious connections with genes, like the BRCA gene that increases the risk for breast cancer, have already been found, Derringer says. Now new methods are letting scientists look for more subtle associations between genes and all kinds of traits, including behavior and personality.

Derringer used a kind of mutation in DNA called a single-nucleotide polymorphism, or SNP. A SNP is a change in just one "letter" of the DNA. She started by picking eight genes with various roles related to the neurotransmitter dopamine, which has been linked to sensation seeking in other studies. She looked at group of 635 people who were part of a study on addiction.

For each one, she had genetic information on 273 SNPs known to appear in those 8 genes and a score for how much they were inclined to sensation seeking. Using that data, she was able to narrow down the 273 SNPs to 12 potentially important ones. When she combined these 12 SNPs, they explained just under 4 percent of the difference between people in sensation seeking. This may not seem like a lot, but it's "quite large for a genetic study," Derringer says.

It's too soon to go out and start screening people for these mutations; not enough is known about how genes affect behavior. "One of the things we think is most exciting about this isn't necessarily the story about dopamine and sensation seeking," says Derringer. "It's rather the method that we're using. We used a sample of 635 people, which is extremely small, and we were still able to detect a significant effect. That's actually quite rare in these studies." She said the same method could be used to look at the link between biology and other behaviors—dopamine and cocaine dependence, for example, or serotonin and depression.

Eventually these methods could lead to tests that might help predict whether someone is likely to have problems later, and whether there should be early intervention to guide them down a healthier path.

For more information about this study, please contact Jaime Derringer at derri023@umn.edu.

The APS journal Psychological Science is the highest ranked empirical journal in psychology. For a copy of the article "Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach" and access to other Psychological Science research findings, please contact Keri Chiodo at 202-293-9300 or kchiodo@psychologicalscience.org

Keri Chiodo | EurekAlert!
Further information:
http://www.psychologicalscience.org

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>