Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A study using Drosophila flies reveals new regulatory mechanisms of cell migration

21.03.2014

The study by Sofia J. Araújo sheds light on the fields of development, wound healing, angiogenesis, and tumour invasion, processes in which cell migration is crucial.


Tracheas of the fruit fly Drosophila melanogaster (in blue and red) are a good model to study cell migration (Author: E Butí, IRB)

A study by Sofia J. Araújo, a Ramón y Cajal researcher with the Morphogenesis in Drosophila lab at the Institute for Research in Biomedicine (IRB), elucidates the genetic regulation of cell migration.

Published today in the scientific journal Plos One, the research is part of the thesis work performed by Elisenda Butí, first author of the article.

... more about:
»Drosophila »mechanisms »regulatory

Cell migration is highly coordinated and occurs in processes such as embryonic development, wound healing, the formation of new blood vessels, and tumour cell invasion. For the successful control of cell movement, this process has to be determined and maintained with great precision.

In this study, the scientists used tracheal cells of the fruit fly Drosophila melanogaster to unravel the signalling mechanism involved in the regulation of cell movements.

The research describes a new molecular component that controls the expression of a molecule named Fibroblast Growth Factor (FGF) in Drosophila embryos. The importance of FGF in cell migration was already known but little information was available on its genetic regulation.

In the study, Araújo and her team have discovered that a protein called Hedgehog, known to be involved in morphogenesis, regulates FGF expression.

“This is the first time that a direct connection has been demonstrated between the Hedgehog pathway and an increase in FGF during cell migration,” says Araújo.

The results are really interesting for biomedicine,” explains the researcher, “as the Hedgehog pathway is overexpressed in some of the most invasive tumours, such as the most common kind of skin cancer.”

The team explains that this is a step forward for research into cell migration mechanisms and that future applications will emerge as further investigation and studies are conducted.

Reference article:
Hedgehog is a positive regulator of FGF signalling during embryonic cell migration
Elisenda Butí, Duarte Mesquita and Sofia J. Araújo
Plos One (2014) 10.1371/journal.pone.0092682

Sònia Armengou | EurekAlert!

Further reports about: Drosophila mechanisms regulatory

More articles from Life Sciences:

nachricht Biology meets geometry
31.10.2014 | University of California - Santa Barbara

nachricht Blocking a Fork in the Road to DNA Replication
31.10.2014 | Whitehead Institute for Biomedical Research

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Registration Open Now: 18th International ESAFORM Conference on Material Forming

28.10.2014 | Event News

Comparing Apples and Oranges? A Colloquium on International Comparative Urban Research

22.10.2014 | Event News

Battery Conference April 2015 in Aachen

16.10.2014 | Event News

 
Latest News

Siemens secures two new orders for wind power projects in Canada

31.10.2014 | Press release

Tropical Storm Vance's Center Looks Like a Pumpkin to NASA's Terra Satellite

31.10.2014 | Earth Sciences

Improved funding for innovative companies: KfW introduces "Entrepreneur Loan Plus"

31.10.2014 | Business and Finance

VideoLinks
B2B-VideoLinks
More VideoLinks >>>