Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A study using Drosophila flies reveals new regulatory mechanisms of cell migration

21.03.2014

The study by Sofia J. Araújo sheds light on the fields of development, wound healing, angiogenesis, and tumour invasion, processes in which cell migration is crucial.

A study by Sofia J. Araújo, a Ramón y Cajal researcher with the Morphogenesis in Drosophila lab at the Institute for Research in Biomedicine (IRB), elucidates the genetic regulation of cell migration.


Tracheas of the fruit fly Drosophila melanogaster (in blue and red) are a good model to study cell migration (Author: E Butí, IRB)

Published today in the scientific journal Plos One, the research is part of the thesis work performed by Elisenda Butí, first author of the article.

Cell migration is highly coordinated and occurs in processes such as embryonic development, wound healing, the formation of new blood vessels, and tumour cell invasion. For the successful control of cell movement, this process has to be determined and maintained with great precision.

... more about:
»Drosophila »mechanisms »regulatory

In this study, the scientists used tracheal cells of the fruit fly Drosophila melanogaster to unravel the signalling mechanism involved in the regulation of cell movements.

The research describes a new molecular component that controls the expression of a molecule named Fibroblast Growth Factor (FGF) in Drosophila embryos. The importance of FGF in cell migration was already known but little information was available on its genetic regulation.

In the study, Araújo and her team have discovered that a protein called Hedgehog, known to be involved in morphogenesis, regulates FGF expression.

“This is the first time that a direct connection has been demonstrated between the Hedgehog pathway and an increase in FGF during cell migration,” says Araújo.

The results are really interesting for biomedicine,” explains the researcher, “as the Hedgehog pathway is overexpressed in some of the most invasive tumours, such as the most common kind of skin cancer.”

The team explains that this is a step forward for research into cell migration mechanisms and that future applications will emerge as further investigation and studies are conducted.

Reference article:
Hedgehog is a positive regulator of FGF signalling during embryonic cell migration
Elisenda Butí, Duarte Mesquita and Sofia J. Araújo
Plos One (2014) 10.1371/journal.pone.0092682

Sònia Armengou | EurekAlert!

Further reports about: Drosophila mechanisms regulatory

More articles from Life Sciences:

nachricht Bare bones: Making bones transparent
27.04.2017 | California Institute of Technology

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>