Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A molecular delivery service

30.08.2013
Tiny hair-like structures (cilia) are found on the surface of most cells. Cilia are responsible for the locomotion of cells (e.g. sperm cells), they process external signals and coordinate the correct arrangement of the inner organs during the development of an organism.

For proper assembly and function of cilia, they need to be supplied with the appropriate building blocks. Scientists at the MPI of Biochemistry (MPIB) in Martinsried near Munich, Germany, now identified the mechanism of how Tubulin, the main building block of cilia, is transported within the cilium. The results now published in the journal Science could help to understand and potentially prevent these diseases.


Building blocks for the assembly of a cilium are transported from the base to the tip of the cilium.
Copyright: Institut Pasteur, Paris

Although cilia fulfill various tasks, they all have a similar structure: They are only five to ten micrometers (0.0005 to 0.001 centimeters) long and are located on the surface of eukaryotic cells. About 600 different ciliary proteins are synthesized inside the cell and then transported into the cilium. Disruption of this transport system, which scientists call intraflagellar transport (IFT), can lead to errors during the assembly of the cilia and thus cause diseases resulting in mental and physical symptoms. Mistakes in ciliary function can for example cause a “situs inversus”, a condition where the left/right arrangement of the inner organs in the body is reversed.

Even though the importance of the intraflagellar transport (IFT) and the cilium to human health has been known for a long time, a structural and mechanistic understanding of IFT has been missing so far. Scientists from the research group “Intraflagellar Transport” headed by Esben Lorentzen now succeeded in identifying the transport mechanism of the key protein Tubulin. It is the most abundant protein in the cilium and forms its backbone. “We found that the two proteins IFT74 and IFT81 work together to form a tubulin-binding module,” says Sagar Bhogaraju. When the researchers disturbed the binding of IFT74 and -81 to tubulin in human cells, it had severe impact on the formation of the cilia. “Our results provide the first glimpse into the assembly of the cilium at the molecular level,” says the biochemist.

Original Publication:
Bhogaraju, S., Cajanek L., Fort, C., Blisnick, T. , Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E. and Lorentzen, E.: Molecular Basis of Tubulin Transport within the Cilium by IFT74 and IFT81, Science, August 30, 2013.

DOI: 10.1126/science.1240985

Contact:
Dr. Esben Lorentzen
Structural Biology of Cilia
Max Planck Institute of Biochemistry
Am Klopferspitz 18
82152 Martinsried
Germany
E-Mail: lorentze@biochem.mpg.de
Anja Konschak
Public Relations
Max Planck Institute of Biochemistry
Am Klopferspitz 18
82152 Martinsried
Germany
Tel. +49 89 8578-2824
E-Mail: konschak@biochem.mpg.de

Weitere Informationen:
http://www.biochem.mpg.de/1890328/074_Lorentzen_IFT
- Link to the Press Release
http://www.biochem.mpg.de/en/news/pressroom
- Press Releases of the MPI of Biochemistry
http://www.biochem.mpg.de/en/rg/lorentzen
- Website of the Research Group "Intraflagellar Transport"

Anja Konschak | Max-Planck-Institut
Further information:
http://www.biochem.mpg.de

Further reports about: Biochemistry IFT74 IFT81 IfT MPI Max Planck Institute Tubulin building block

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>