Other neurodegenerative disorders like Alzheimer’s disease, Creutzfeld-Jakob disease and Parkinson’s disease are also associated with protein misfolding and aggregation.
Anna Nordlung and Mikael Oliveberg from the Department of Biochemistry and Biophysics, in Stockholm University, in Sweden have been studying the folding and assembly pathway of the SOD1 dimer and how this is affected by ALS-provoking mutations.In a Perspective published in the HFSP Journal, they argue that the relative ease with which such data can be obtained for SOD1 makes it a promising model for elucidating also the origin of other neurodegenerative diseases where the precursor proteins are structurally more
This Perspective is part of a special issue on protein folding, which also features:
• a Perspective by Adriano Aguzzi from the University of Zurich that discusses the relevance of protein folding or misfolding to Creutzfeld-Jakob disease
• Perspective review articles by Peter Wolynes from the University of California at San Diego, Victor Munoz from the Spanish Research Council and Jane Clarke from Cambridge University and an article by Koby Levy from the Weizmann Institute in Israel that discuss the physics and biophysics of protein folding
• Perspectives by Martin Gruebele from the University of Illinois and Edward Engelman from the University of Virginia and Commentaries by Pal Ormos from the Hungarian Academy of Sciences and Thomas Schneider from the European Molecular Biology Laboratory in Germany and that present new experimental advances that have allowed for probing in details of protein structure, folding and dynamics
• Finally, articles by Sophie Jackson from Cambridge University and Lisa Lapidus from Michigan State University describe the folding of the model protein green fluorescent protein GFP and protein L respectively, and an article by Martin Mann from the University of Freiburg, Germany presents a computational model to predict protein folding and three-dimensional structures.
This special issue was Edited by Jose’ Onuchic from the Center for Theoretical Biological Physics and Department of Physics of the University of California at San Diego.
Valerie Ferrier | alfa
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Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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