Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A model system to elucidate the origin of protein-misfolding neurodegenerative diseases

28.11.2008
Amyotropic lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding and aggregation of the dimers of the enzyme superoxide dismutase (SOD1).

Other neurodegenerative disorders like Alzheimer’s disease, Creutzfeld-Jakob disease and Parkinson’s disease are also associated with protein misfolding and aggregation.

Anna Nordlung and Mikael Oliveberg from the Department of Biochemistry and Biophysics, in Stockholm University, in Sweden have been studying the folding and assembly pathway of the SOD1 dimer and how this is affected by ALS-provoking mutations.

In a Perspective published in the HFSP Journal, they argue that the relative ease with which such data can be obtained for SOD1 makes it a promising model for elucidating also the origin of other neurodegenerative diseases where the precursor proteins are structurally more

elusive.

This Perspective is part of a special issue on protein folding, which also features:

• a Perspective by Adriano Aguzzi from the University of Zurich that discusses the relevance of protein folding or misfolding to Creutzfeld-Jakob disease

• Perspective review articles by Peter Wolynes from the University of California at San Diego, Victor Munoz from the Spanish Research Council and Jane Clarke from Cambridge University and an article by Koby Levy from the Weizmann Institute in Israel that discuss the physics and biophysics of protein folding

• Perspectives by Martin Gruebele from the University of Illinois and Edward Engelman from the University of Virginia and Commentaries by Pal Ormos from the Hungarian Academy of Sciences and Thomas Schneider from the European Molecular Biology Laboratory in Germany and that present new experimental advances that have allowed for probing in details of protein structure, folding and dynamics

• Finally, articles by Sophie Jackson from Cambridge University and Lisa Lapidus from Michigan State University describe the folding of the model protein green fluorescent protein GFP and protein L respectively, and an article by Martin Mann from the University of Freiburg, Germany presents a computational model to predict protein folding and three-dimensional structures.

This special issue was Edited by Jose’ Onuchic from the Center for Theoretical Biological Physics and Department of Physics of the University of California at San Diego.

Valerie Ferrier | alfa
Further information:
http://hfspj.aip.org

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
21.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
21.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>