Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening

16.05.2012
Authors suggest it could help in preoperative diagnosis along with other methods

The most recent research released in June's Journal of Thoracic Oncology says molecular biomarkers in the tissue and fluid lining the lungs might be an additional predictive technique for lung cancer screening.

Since the National Lung Screening Trial found that 96.4 percent of the positive CT screening results were false positive, scientists have been looking for ways to more accurately diagnose patients. This research focused on a way to determine if the nodules detected by the CT screening, are in fact malignant or benign.

The study presented in the June 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology collected endobronchial epithelial-lining fluid (ELF) near a lung nodule using bronchoscopic microsampling, which is a less invasive procedure compared to surgery.

After studying 142 ELF samples from 71 patients with pulmonary nodules, some cancerous, others non cancerous, the authors conclude that, "TNC (tenasin-C) gene expression and the nodule size are two independent factors that improved the prediction of lung cancer. However this finding has to be verified in larger cohorts."

The authors point out that in previous research, "tumor markers like CEA and CYFRA were found to be in higher abundance in ELF close to the small peripheral lung carcinoma when compared to the contralateral site or benign cases."

The lead authors of this work include: Dr. Nicolas Kahn, Thoraxklinik University of Heidelberg; Philipp Schnabel, Institute of Pathology in Heidelberg; and Prof. Ruprecht Kuner, German Cancer Research Center Heidelberg. Other IASLC member co-authors include: Michael Meister, Thomas Muley and Dr. Felix Herth.
About the IASLC:

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit www.iaslc.org.

Kristal Griffith | EurekAlert!
Further information:
http://www.IASLC.org

Further reports about: CT screening Cancer IASLC Oncology Thoracic lung cancer

More articles from Life Sciences:

nachricht Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY

nachricht Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>