Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new interplay between the reproductive germline and the body

26.08.2013
Dr. Björn Schumacher’s team at the University of Cologne uncovers a new type of communication through which germ cells (the precursors to sperm and eggs) instruct the body to increase its resistance to various types of stress.

When the DNA of germ cells is damaged, the production of offspring must be delayed until the genetic material is repaired. By studying the nematode worm model Caenorhabditis elegans, the researchers found that to gain more time to repair their DNA, germ cells activate the innate immune system that then triggers enhanced endurance of other body tissues.

Now, for the first time, it is clear how germ cells can influence the reproductive lifespan of the body when they require more time to guarantee accurate passage of the genetic material to the next generation. Moreover, the new insights might lead to a better understanding how the immune system mediates systemic responses to DNA damage, a process that plays an important role in the natural defense against cancer.

From generation to generation, the genetic material needs to be transmitted through the germline, where germ cells produce sperm and egg cells. The maintenance of the genome in germ cells is thus a prerequisite for the survival of the species. While germ cells continue their lives endlessly as they carry the genetic information to future generations, the somatic tissues (all non-reproductive cells of the body) function as their ever-ageing carriers. But how does the whole organism respond when the genome of germ cells is damaged thus preventing them from generating offspring?

In the current issue of Nature, Björn Schumacher’s group at the Excellence Cluster for Ageing Research at the University of Cologne reports a novel type of interplay between the germline and the somatic tissues. Strikingly, they found that the immune system alerts the body when germ cells are damaged. The scientists revealed that when the genome of germ cells is damaged, somatic tissues respond by elevated resistance to various stress factors. The increased stress resistance makes the somatic tissues more durable and enables the body to survive the stress longer, thus “buying” time to postpone progeny production until the germ cells have repaired their DNA.

The Cologne biologists identified the novel influence of the germline on somatic tissues by studying the simple nematode worm Caenorhabditis elegans. The worm is widely used as important model system because many biological processes that are relevant to human health are also present. Germ cells halt their activity when their genomes are damaged, thus halting offspring production. Schumacher’s team observed that the damaged germ cells produce innate immune factors that are normally secreted in the intestine when the worms have ingested pathogens. Indeed, the innate immune response to DNA damage in the germ cells made the worms more resistant to pathogen infection. In addition, the somatic tissues became highly durable even under environmental stress conditions. Furthermore, in the somatic tissues, the innate immune response led to elevated quality control of proteins, which contributed to this increased stress resistance. The scientists named this new phenomenon “germline DNA damage-induced systemic stress resistance” (GDISR).

The activation of innate immune responses to DNA damage is relevant for fighting cancer cells in humans. DNA damage in somatic human cells can lead to mutations that can transform cells into cancer cells. The human immune system reacts to the damaged cells in the body by eliminating them; however, some cancer cells acquire mutations that allow them to disguise themselves from the immune system and continue to grow. The new results from the Schumacher group provide a basis for the investigation of innate immune responses to DNA damage in a very simple biological system. These mechanisms might then enable the development of therapies that activate the immune system to effectively eliminate cancer cells.

It will be particularly interesting to investigate how the human body responds when the germ cells’ genomes are compromised. The foundation is now laid for better understanding how the human body responds to DNA damage in germ cells and how the reproductive capacity might be prolonged when germ cells require time to repair their genome.

Christoph Wanko | idw
Further information:
http://cecad.uni-koeln.de/

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>