In the journal Angewandte Chemie, Eugene R. Zubarev and his team at Rice University in Houston (Texas, USA) have now introduced a new pretreatment process for gold nanorods that could accelerate their use in medical applications.
How can tiny rods of gold help to fight cancer? Cancer cells are more sensitive to temperature than healthy tissue, and this fact can be exploited through local heating of the affected parts of the body. This is where the gold nanorods come into play. They can be introduced into the cancer cells and the diseased areas irradiated with near-infrared light (photoinduced hyperthermia). The rods absorb this light very strongly and transform the light energy into heat, which they transfer to their surroundings.
Gold nanorods are normally produced in a concentrated solution of cetyl trimethylammonium bromide (CTAB) and are thus coated in a double layer of CTAB. The CTAB is only deposited onto the surface, not chemically bound. In an aqueous environment, the CTAB molecules slowly dissolve. This is problematic because CTAB is highly toxic. Simply leaving out the CTAB is no solution because without this coating the nanorods would clump together.
In order to make the rods stable as well as biocompatible, various more or less complex methods of pretreatment have been developed. However, for many of these processes, it is not known how much of the toxic CTAB remains on the nanorods. Another problem is that the pretreatment can disrupt the uptake of the nanorods into cells, which drastically reduces the success of photothermal cancer treatment.Zubarev and his co-workers have now developed a new strategy that solves these problems: they replaced the CTAB with a variant that contains a sulfur-hydrogen group, abbreviated as MTAB. With various analytical processes, the scientists have been able to prove that the CTAB on these nanorods is completely replaced with an MTAB layer. The MTAB molecules chemically bond to gold nanorods through their sulfur atoms. They bind so tightly that the layer stays in place even in an aqueous solution and the rods can even be freeze-dried. They can be stored indefinitely as a brown powder and dissolve in water again within seconds.
Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201107304
Eugene R. Zubarev | Angewandte Chemie
New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego
Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
16.01.2018 | Materials Sciences
16.01.2018 | Materials Sciences
16.01.2018 | Power and Electrical Engineering