Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A Breakthrough for Organic Reactions in Water

27.06.2014

Researchers discover way to use water as solvent in a reaction widely used to make chemical products

Green-chemistry researchers at McGill University have discovered a way to use water as a solvent in one of the reactions most widely used to synthesize chemical products and pharmaceuticals.

The findings, published June 26 in Nature Communications, mark a potential milestone in efforts to develop organic reactions in water.

Chao-Jun Li and Feng Zhou of McGill’s Department of Chemistry report that they have discovered a catalytic system which for the first time allows direct metal-mediated reactions between aryl halides and carbonyl compounds in water.

For the past two decades, researchers have been exploring ways to do away with chemists’ traditional reliance on non-renewable petrochemical feedstocks and toxic solvents. One important method has involved replacing the toxic solvents used in metal-mediated reactions with water – something that was previously considered impossible.

While researchers at McGill and elsewhere have succeeded in using water in metal-mediated reactions between carbonyl compounds and other halides, attempts to do so for the most challenging reaction, between aryl halides and carbonyl compounds, have never worked – until now.

Prof. Li and Dr. Zhou, a postdoctoral fellow, found that rhodium -- a metal primarily used in the catalytic converters of automobiles -- as a catalyst together with zinc as a mediator can make the reaction possible in water. This new technique bypasses a number of challenges posed by conventional practices in carrying out this reaction, which is widely used in synthesizing fine chemicals, biologically active molecules and pharmaceuticals. Traditional methods, discovered more than a century ago, require that moisture and air be carefully excluded from the process.

The new aqueous approach promises to “streamline synthetic sequences and make them safer and more efficient,” said Prof. Li, Canada Research Chair in Green Chemistry.

The research was supported by the Canada Research Chairs program, the Fonds de recherche du Québec – Nature et technologies, the Natural Sciences and Engineering Research Council of Canada, and the Canada Foundation for Innovation.

“The Barbier-Grignard-Type Carbonyl Arylation Using Unactivated Aryl Halides in Water”, Feng Zhou and Chao-Jun Li, Nature Communications, published June 26, 2014. DOI: 10.1038/ncomms5254

Christopher Chipello | newswise
Further information:
http://www.mcgill.ca

Further reports about: Breakthrough McGill Water compounds discovered moisture reaction reactions technique toxic

More articles from Life Sciences:

nachricht Team pinpoints genes that make plant stem cells, revealing origin of beefsteak tomatoes
26.05.2015 | Cold Spring Harbor Laboratory

nachricht DNA double helix does double duty in assembling arrays of nanoparticles
26.05.2015 | DOE/Brookhaven National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

Im Focus: First electrical car ferry in the world in operation in Norway now

  • Siemens delivers electric propulsion system and charging stations with lithium-ion batteries charged from hydro power
  • Ferry only uses 150 kilowatt hours (kWh) per route and reduces cost of fuel by 60 percent
  • Milestone on the road to operating emission-free ferries

The world's first electrical car and passenger ferry powered by batteries has entered service in Norway. The ferry only uses 150 kWh per route, which...

Im Focus: Into the ice – RV Polarstern opens the arctic season by setting course for Spitsbergen

On Tuesday, 19 May 2015 the research icebreaker Polarstern will leave its home port in Bremerhaven, setting a course for the Arctic. Led by Dr Ilka Peeken from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) a team of 53 researchers from 11 countries will investigate the effects of climate change in the Arctic, from the surface ice floes down to the seafloor.

RV Polarstern will enter the sea-ice zone north of Spitsbergen. Covering two shallow regions on their way to deeper waters, the scientists on board will focus...

Im Focus: Gel filled with nanosponges cleans up MRSA infections

Nanoengineers at the University of California, San Diego developed a gel filled with toxin-absorbing nanosponges that could lead to an effective treatment for skin and wound infections caused by MRSA (methicillin-resistant Staphylococcus aureus), an antibiotic-resistant bacteria. This "nanosponge-hydrogel" minimized the growth of skin lesions on mice infected with MRSA - without the use of antibiotics. The researchers recently published their findings online in Advanced Materials.

To make the nanosponge-hydrogel, the team mixed nanosponges, which are nanoparticles that absorb dangerous toxins produced by MRSA, E. coli and other...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Analytical lamps monitor air pollution in cities

26.05.2015 | Ecology, The Environment and Conservation

DNA double helix does double duty in assembling arrays of nanoparticles

26.05.2015 | Life Sciences

Turn That Defect Upside Down

26.05.2015 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>