Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

'Spaghetti' scaffolding could help grow skin in labs

20.10.2009
Scientists are developing new scaffolding technology which could be used to grow tissues such as skin, nerves and cartilage using 3D spaghetti-like structures. Their research is highlighted in the latest issue of Business, the quarterly highlights magazine of the Biotechnology and Biological Sciences Research Council (BBSRC).

The new structures are being developed by scientists from the University of Bristol, using proteins from alpha helices – one of the fundamental ways that strings of amino acids fold - to create long fibres called hydrogelating self assembling fibres (hSAFs), or hydrogels. By learning how to build hSAFs from scratch, the researchers are starting to understand how they might use these 3D scaffolds to support the growth of nerves, blood vessels and cartilage tailored to the needs of individual patients.

Professor Dek Woolfson who is leading the work, explains: "To make hydrogels you need something long and thin that will interact with copies of itself and form meshes, but is also water soluble. However rather than using natural proteins, which are complex, we've tried to make something as simple as possible that we fully understand using peptides and self assembling proteins."

Currently, hydrogel scaffold structures, made either synthetically or from natural resources such as seaweed, are used in everyday products from shampoos to drug capsules.

But explains, Professor Woolfson, the hSAFs his team are developing will have different uses: "The downside of using peptides or proteins is that they are expensive compared with synthetic polymers. We are almost certainly looking at high end biomedical applications, generating cells which can be used in living systems. Potential medical benefits include growing tissues such as skin, nerves and cartilage in the laboratory which will advance basic research and may lead to biomedical applications like speeding up wound healing and grafting."

Commenting on the research, BBSRC Chief Executive Professor Doug Kell, said: "This research highlights the importance of understanding how things work at a micro level and then looking at different ways to apply this knowledge to create effective solutions for tackling everyday problems, in this instance, translating basic bioscience into technology which could have very real clinical benefits for patients."

This research is featured in the latest edition of Business, the quarterly magazine of BBSRC.

Contact

BBSRC Media Office
Tracey Jewitt, Tel: 01793 414694, email: tracey.jewitt@bbsrc.ac.uk
Nancy Mendoza, Tel: 01793 413355, email: nancy.mendoza@bbsrc.ac.uk
Matt Goode, Tel: 01793 413299, email: matt.goode@bbsrc.ac.uk
NOTES TO EDITORS
This research features in the Autumn 2009 issue of Business, BBSRC's research highlights magazine.
To read the full article, visit: http://www.bbsrc.ac.uk/publications/business/2009/autumn/feature_protein

_spaghetti_tissue_engineering.html

About BBSRC

The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450 million in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. BBSRC carries out its mission by funding internationally competitive research, providing training in the biosciences, fostering opportunities for knowledge transfer and innovation and promoting interaction with the public and other stakeholders on issues of scientific interest in universities, centres and institutes.

The Babraham Institute, Institute for Animal Health, Institute of Food Research, John Innes Centre and Rothamsted Research are Institutes of BBSRC. The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.

Tracey Jewitt | EurekAlert!
Further information:
http://www.bbsrc.ac.uk

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>