As partners in the international research consortium named MetaHit, scientists from the University of Copenhagen have contributed to show that an individual's intestinal bacteria flora, regardless of nationality, gender and age, organises itself in certain clusters.
The cluster of intestinal bacteria flora is hypothesised to have an influence on how we react to both our diet and medicine absorbed through the gastro-intestinal tract. The results have recently been published in the journal Nature.
Most people know about blood types, some also know about tissue types. However, now we may need to consider intestinal bacteria types as well. As part of a large, international research consortium, scientists from the University of Copenhagen have recently contributed to map special "enterotypes", which are three distinctive clusters of bacteria in the human distal gut. Each of these enterotypes reflects a certain balance between various categories of bacteria in the distal gut, and is thought to impact intestinal bacteria digest food leavings, and utilise these for energy delivery to the gut and the whole body energy metabolism, and on how various drugs are absorbed through the gastrointestinal tract.
The outcome of the project has recently been reported in the journal Nature's online publication for results that deserve immediate exposure.
"The discovery of enterotypes is expected to influence future research within a number of fields," explains Professor Oluf Borbye Pedersen, professor at Novo Nordisk Foundation Center for Basic Metabolic Research at the Faculty of Health Sciences, the University of Copenhagen, and also one of the lead investigators in the international research consortium MetaHIT, which has conducted the project.
"Our results show that we may have uncovered a new 'biological fingerprint' on the same level as blood types and tissue types. The three enterotypes occur across nationalities and are independent of gender and age. Every enterotype has a certain composition of bacteria that have specific functions, for example energy production from degradation of dietary fibres or formation of certain vitamins. This may potentially affect a number of biological functions – discoveries which at a later stage may be translated into individual diet advice or design of drugs that are adapted to the individual enterotype," Oluf Borbye Pedersen adds.
He underlines that the results published in Nature do not show anything about the precise mechanisms by which the three enterotypes individually affect people that host the bacteria. After further research, more intestinal bacteria clusters will most likely be added to the three enterotypes, which have been identified so far. However, the discovery of their existence gives researchers new opportunities for studying how the about 1.5-kilo gut bacteria, which we all have in our digestive system, affects our health.
The researchers from MetaHIT, an international EU-supported project, have studied 278 volunteers in total from Denmark, Italy, Spain, France, Japan and USA for the paper in Nature. From Denmark, several scientists have contributed from the Novo Nordisk Foundation Center for Basic Metabolic Research at Faculty of Health Sciences, University of Copenhagen; the Lundbeck Foundations Genomics Center, LuCamp; and from the Center for Biological Sequence Analysis, Institute for System Biology at the Technical University of Denmark.
Prof Oluf Borbye Pedersen | EurekAlert!
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences