Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New 'magnetic yeast' marks step toward harnessing Nature's magnetic capabilities

29.02.2012
Researchers at Harvard's Wyss Institute and Harvard Medical School induce magnetic sensitivity in a non-magnetic organism

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School have developed a method for inducing magnetic sensitivity in an organism that is not naturally magnetic—yeast. Their technology could potentially be used to magnetize a variety of different cell types in medical, industrial and research applications. The research findings appear in today's issue of PLoS Biology.

Magnetic fields are everywhere, but few organisms can sense them. Those that do, such as birds and butterflies, use magnetic sensitivity as a kind of natural global positioning system to guide them along migratory routes. How these few magnetically aware organisms gain their magnetism remains one of biology's unsolved mysteries.

Researchers Pamela Silver, Ph.D., and Keiji Nishida, Ph.D., were able to imbue yeast with similar properties. Silver, the principal investigator, is a founding core faculty member at the Wyss Institute and a professor of Biochemistry and Systems Biology at Harvard Medical School (HMS). Nishida is a research fellow in Systems Biology at HMS.

"Magnetism in nature is a unique and mysterious biological function that very few living systems exploit," said Silver. "So while magnetic yeast may not sound like a serious scientific breakthrough, it's actually a highly significant first step toward harnessing this natural phenomenon and applying it to all sorts of important practical purposes."

The presence of iron can cause magnetism, but most cells, if exposed to this common metal, hide it away in sealed-off cavities where it cannot have an effect. Silver and Nishida were able to block expression of the protein that causes the iron sequestration, allowing the iron to circulate freely throughout the yeast cell. In this way, they created enough magnetic sensitivity in the cell to cause it to migrate toward an external magnet.

The researchers also found a gene that correlates with magnetism by instructing the production of a critical protein that can dial up magnetism. They then enhanced the magnetic sensitivity even further through interaction with a second protein that regulates cell metabolism. Since the same metabolic protein functions similarly in cells ranging from simple yeast to more advanced—even human—cells, the new method could potentially be applied to a much wider range of organisms.

Silver notes that in an industrial setting, magnetization could be extremely helpful as a means of targeting and isolating specific cells. Contaminated cells could be pulled out and disposed of during the processing of biological materials, and cells that are critical to a certain manufacturing process could be isolated and put to use. Magnetic cells could also be used to interact with non-living machinery. For example, magnetism could be used in tissue engineering to guide cells to layer themselves on a scaffold in a specific way. New therapies might one day be created in which cells are engineered to respond to a magnetic field by growing or healing, and implanted magnetic stem cells might one day be tracked with magnetic resonance imaging.

"This work shows how design principles from one type of cell can be harnessed using synthetic biology to transfer novel functionalities to another, which is a core approach driving the field of biologically inspired engineering," said Wyss Institute Founding Director Donald Ingber, M.D. Ph.D. Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Children's Hospital Boston, and Professor of Bioengineering at Harvard's School of Engineering and Applied Sciences. "The ability to control cells magnetically will also synergize with many other technologies in the pipeline at the Wyss Institute that rely on use of magnetic fields to control cell functions remotely, or to isolate rare cells from biological fluids."

About the Wyss Institute for Biologically Inspired Engineering at Harvard University

The Wyss Institute for Biologically Inspired Engineering at Harvard University (http://wyss.harvard.edu) uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital Boston, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, and Boston University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs. By emulating Nature's principles for self-organizing and self-regulating, Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and new start-ups.

Twig Mowatt | EurekAlert!
Further information:
http://wyss.harvard.edu

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>