Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Deciphering how arteries contribute to hypertension

11.06.2003


National Insitute of Standards and Technology (NIST) scientists are taking their knowledge of mechanical tensile strength tests in metals and composites and applying it to medical research problems. Doctors long have known that babies born with congenital heart defects at higher altitudes have an increased risk of developing complications, such as pulmonary hypertension. Could there be some way to trick the arterial walls so that they wouldn’t stiffen under increased blood pressure?



Working with the Children’s Hospital and University of Colorado Health Sciences Center in Denver, NIST researchers have used rat arteries--both normal and hypertensive--supplied by the university center and placed them in a mechanical stress tester. The tester holds a small disc-shaped sample of the arterial tissue that is slowly stretched by pumping a special liquid against the back of the disc. The pressure of the liquid causes a bubble to form on the front of the disc. The shape of the resulting bubble helps the researchers determine details about the tissues’ elasticity, strength, stiffness and other properties.

" Hypertensive tissue should be stiffer, so we will get less inflation with the same amount of pressure," says NIST researcher Elizabeth Drexler. "What we want to know is what it is in the artery that causes it to stiffen. Is it more collagen? Is it the smooth muscle cells? Perhaps we could give the muscle cell a signal not to produce more collagen." So far they have studied 20 rat arteries and plan to study 20 more, along with some calf arteries. A preliminary report that verifies their test method appears in the May/June issue of the NIST Journal of Research.


Fred McGehan | EurekAlert!
Further information:
http://www.nist.gov/

More articles from Interdisciplinary Research:

nachricht A new method for the 3-D printing of living tissues
16.08.2017 | University of Oxford

nachricht Bergamotene - alluring and lethal for Manduca sexta
21.04.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Interdisciplinary Research >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>