Researchers at Los Alamos National Laboratory and the University of California, San Diego, have created the first computer simulation of full-system protein folding thermodynamics at the atomic-level. Understanding the basic physics of protein folding could solve one of the grand mysteries of computational biology.
Proteins are the basic building blocks of life and protein folding, the process by which proteins reconfigure themselves - the actions that result in structural change - are the foundation of cellular growth and the health of a biological system. When proteins incorrectly fold the malfunction can give rise to a variety of diseases. The fact that proteins fold has been known since the 1960s, but an understanding of the chemical and physical properties of folding continues to elude scientists.
Understanding how proteins undergo the folding process has largely been studied from a biologist’s point of view, probing actual proteins and studying them with high-powered microscopy techniques. Now, Los Alamos theoretical biophysicist Angel Garcia, along with colleague Jose N. Onuchic of UC San Diego, have created a computer model of protein folding that focuses on the physics of the protein folding, specifically looking at the temperature changes that occur in the process.
Kevin Roark | EurekAlert!
Lego-like wall produces acoustic holograms
17.10.2016 | Duke University
New evidence on terrestrial and oceanic responses to climate change over last millennium
11.10.2016 | University of Granada
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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