CARS Explorer is a collaborative research project funded by the European Commission under the Health priority of the 7th Framework Programme. This highly interdisciplinary consortium brings together internationally renowned physicists, biologists and clinicians of six institutional bodies from four European countries and a French SME.
Financed for three years, CARS Explorer seeks to demonstrate the concept of innovative light-based contrasting technologies for functional in situ imaging in life science and biomedical research. The ultimate goal of the consortium is to develop an endoscope based on non-linear optics (NLO) and laser pulse phase shaping.
Today, NLO technologies allow primarily low-depth exploration. However, they present major opportunities at the morphological and molecular level which makes it an original tool for biomedical analysis without requiring preliminary sample preparation, thus providing real time information to the patients.
To bring the concept to the diagnostic level, Cars Explorer partners will explore the molecular and morphological NLO signatures associated with tumour development in skin cancer, one of the fastest growing cancers in Europe with an incidence increase of 5 to 7 % a year. (Source: Ligue contre le Cancer). The consortium will concentrate its efforts on the so designated Coherent Anti-Stokes Raman Scattering (CARS) microscopy technique which permits to produce real time 3D images of cells and tissues at a molecular level, without any labelling or staining.
The development of this novel imaging technology will allow an efficient use of our knowledge of cancer molecular modifications. Indeed, this project will have a major strategic and economic impact by providing a non-invasive functional exploration method for clinical research and treatment, in particular for the prevention, diagnosis and monitoring of cancer. In the end, “an imaging technology capable of providing in vivo information both at the cellular and molecular level would be an outstanding and decisive breakthrough. It is certain that such approaches will play an increasingly central part in oncology and clinical research as well in the treatment of patients affected by cancer” says Didier Marguet.
The CARS Explorer consortium is coordinated by the French National Institute for the Health and Medical research (Inserm) and includes the French National Centre for Scientific Research (CNRS), the de Duve Institute (Belgium), the University of Stuttgart (Germany), the University of Bath (UK), Mauna Kea Technologies SAS (a French SME specialised in minimally-invasive biomedical imaging) and Inserm Transfert SA (France).
Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs
07.11.2017 | Technische Universität München
NRL clarifies valley polarization for electronic and optoelectronic technologies
20.10.2017 | Naval Research Laboratory
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
20.11.2017 | Earth Sciences
20.11.2017 | Earth Sciences
20.11.2017 | Life Sciences