Whether resulting from illness or injury, loss of facial bones poses problems for reconstructive surgeons beyond cosmetic implications: The patient's chewing, swallowing, speaking or even breathing abilities may be impaired.
"The mid-face is perhaps the most complicated part of the human skeleton," said Glaucio Paulino, the Donald Biggar Willett Professor of Engineering at U. of I. "What makes mid-face reconstruction more complicated is its unusual unique shape (bones are small and delicate) and functions, and its location in an area susceptible to high contamination with bacteria."
To fashion bone replacements, surgeons often will harvest bone from elsewhere in the patient's body – the shoulder blade or hip, for example – and manually fashion it into something resembling the missing skull portion. However, since other bones are very different from facial bones in structure, patients may still suffer impaired function or cosmetic distortion.
The interdisciplinary research team, whose research results will be published in the July 12 edition of the Proceedings of the National Academy of Sciences, applied an engineering design technique called topology optimization. The approach uses extensive 3-D modeling to design structures that need to support specific loads in a confined space, and is often used to engineer high-rise buildings, car parts and other structures.
"It tells you where to put material and where to create holes," said Paulino, a professor of civil and environmental engineering. "Essentially, the technique allows engineers to find the best solution that satisfies design requirements and constraints."
Facial reconstruction seemed a natural fit for the technique, Paulino said. "We looked at the clinical problem from a different perspective. Topology optimization offers an interdisciplinary framework to integrate concepts from medicine, biology, numerical methods, mechanics, and computations."
Topology optimization would create patient-specific, case-by-case designs for tissue-engineered bone replacements. First, the researchers construct a detailed 3-D computer model of the patient in question and specify a design domain based on the injury and missing bone parts. Then a series of algorithms creates a customized, optimized structure, accounting for variables including blood flow, sinus cavities, chewing forces and soft tissue support, among other considerations. The researchers can then model the process of inserting the replacement bone into the patient and how the patient would look.
"Ideally, it would allow the physician to explore surgical alternatives and to design patient-specific bone replacement. Each patient's bone replacement designs are tailored for their missing volume and functional requirements," Paulino said.
Now that they have demonstrated the concept successfully by modeling several different types of facial bone replacements, the researchers hope to work toward developing scaffolds for tissue engineering so that their designs could be translated to actual bones. They also hope to explore further surgical possibilities for their method.
"This technique has the potential to pave the way toward development of tissue engineering methods to create custom fabricated living bone replacements in optimum shapes and amounts," Paulino said. "The possibilities are immense and we feel that we are just in the beginning of the process."
Also on the U. of I. team is graduate student Tam Nguyen. The Ohio team, sponsored by the National Science Foundation, includes Alok Sutradhar, one of Paulino's former students, and Dr. Michael Miller at the Ohio State University Medical Center Division of Plastic Surgery.
Editor's note: To reach Glaucio Paulino, call 217-333-3817; e-mail email@example.com
Liz Ahlberg | EurekAlert!
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