Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Webcam technology used to measure medications' effects on the heart

04.05.2011
Researchers use basic webcam technology to measure the effects of medications on the heart in real time

A common component in webcams may help drug makers and prescribers address a common side-effect of drugs called cardiotoxicity, an unhealthy change in the way the heart beats. Researchers at Brigham and Women's Hospital (BWH) have used the basic webcam technology to create a tool to look at the effects of medications in real time on heart cells, called cardiomyocytes. These findings were published in the journal, Lab on a Chip on April 11, 2011.

Researchers developed a cost-effective, portable cell-based biosensor for real time cardiotoxicity detection using an image sensor from a webcam. They took cardiomyocytes, derived from mouse stem cells, and introduced the cells to different drugs. Using the biosensor, the researchers were able to monitor the beating rate of the cardiomyocytes in real time and detect any drug-induced changes in the beating rates.

The technology provides a simple approach to perform evaluative studies of different drugs effects on cardiac cells. Cardiotoxicity is a significant problem in drug development, with more than 30 percent of drugs withdrawn from the market between 1996 to 2006 related to cardiac dysfunction. "Assessing the toxic effects of new drugs during the early phases of drug development can accelerate the drug discovery process, resulting in significant cost and time savings, and leading to faster treatment discovery," said Ali Khademhosseini, PhD, of the Center for Biomedical Engineering at the Department of Medicine at BWH.

"This technology could also play a role in personalized medicine," said Sang Bok Kim, PhD, a Research Fellow in the Renal Division at BWH. "By first extracting somatic cells from patients which can be reprogrammed to stem cells called induced pluripotent stem (iPS) cells. Then these iPS cells can be differentiated into cardiac cells to be studied, the biosensor can monitor the cardiac cells as they're introduced to a medication, providing a glimpse at how the drugs may affect the individual's heart, and thus shaping the treatment plan for that person."

Monitoring cardiac cells in the past required using expensive equipment that had a limited measurement area. This low cost (less than $10) biosensor is compatible with conventional equipment but will enable reliable, yet faster and more cost-effective studies.

"Our next goal is to combine our detection sensor with our microwell arrays and perform screening studies of thousands of drugs to cardiac cells simultaneously in a fast and reliable manner," said Dr. Khademhosseini.

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), www.brighamandwomens.org/research, BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative. For more information about BWH, please visit www.brighamandwomens.org

Holly Brown-Ayers | EurekAlert!
Further information:
http://www.brighamandwomens.org

More articles from Information Technology:

nachricht Powerful IT security for the car of the future – research alliance develops new approaches
25.05.2018 | Universität Ulm

nachricht Supercomputing the emergence of material behavior
18.05.2018 | University of Texas at Austin, Texas Advanced Computing Center

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>