In the quest for new cancer drugs, this software supports the full workflow from cell detection to visualization and exploration. As live cells are studied, the results have a higher biological significance and allow characterizing active agents more precisely.
Bayer HealthCare Pharmaceuticals uses FIT's Zeta software in their high content drug research, a technology for discovering active pharmaceutical ingredients. The Zeta software is used to determine the cell division rate of cancer cells in live cell imaging, which allows characterizing active pharmaceutical ingredients much more precisely. Zeta helps to determine cell cycle phases and to monitor the cells across their full life cycle. Substances that affect the division rate of cancerous cells and change it in the desired direction may turn out to be a first active ingredient candidate which will then be further characterized and optimized.
With the Zeta software it is possible to track individual cells across their full life cycle and to monitor several cell generations. A special visualization tool makes it easy to explore the data, to find individual differences and to determine the causes for different reactions of the cells. With single assays the temporal kinetics of an effect can be studied or the start or the maximum of a substance's effect can be determined. The substance – and the structures they affect – can thus be characterized more precisely.
Specific markers are needed to identify the different phases of the cell cycle. Checkpoints that mark the transition from one phase to the next must be made visible for an automated analysis. Here we rely on a cell line from ChromoTek GmbH based on the Chromobody® technology, which was specifically developed for live cell imaging in high content drug research.
The Zeta software offers a simple and intuitive way to analyze complex processes during cell division. An easy-to-use interface guides the user through the complete analysis workflow. User interaction is required at important steps, in order to keep the analysis flexible and to let the user tailor the workflow to changing experimental requirements. One distinctive feature of Zeta is its plug-in architecture, which allows very flexible adaptation of the software. At program start a configuration file is used to load only those modules that are needed for the image analysis at hand. This modular architecture makes it easy to adapt Zeta to new analysis workflows.Contact:
Alex Deeg | Fraunhofer-Institut
World's thinnest hologram paves path to new 3-D world
18.05.2017 | RMIT University
Internet of things made simple: One sensor package does work of many
11.05.2017 | Carnegie Mellon University
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
22.05.2017 | Event News
17.05.2017 | Event News
16.05.2017 | Event News
22.05.2017 | Materials Sciences
22.05.2017 | Life Sciences
22.05.2017 | Physics and Astronomy