In the quest for new cancer drugs, this software supports the full workflow from cell detection to visualization and exploration. As live cells are studied, the results have a higher biological significance and allow characterizing active agents more precisely.
Bayer HealthCare Pharmaceuticals uses FIT's Zeta software in their high content drug research, a technology for discovering active pharmaceutical ingredients. The Zeta software is used to determine the cell division rate of cancer cells in live cell imaging, which allows characterizing active pharmaceutical ingredients much more precisely. Zeta helps to determine cell cycle phases and to monitor the cells across their full life cycle. Substances that affect the division rate of cancerous cells and change it in the desired direction may turn out to be a first active ingredient candidate which will then be further characterized and optimized.
With the Zeta software it is possible to track individual cells across their full life cycle and to monitor several cell generations. A special visualization tool makes it easy to explore the data, to find individual differences and to determine the causes for different reactions of the cells. With single assays the temporal kinetics of an effect can be studied or the start or the maximum of a substance's effect can be determined. The substance – and the structures they affect – can thus be characterized more precisely.
Specific markers are needed to identify the different phases of the cell cycle. Checkpoints that mark the transition from one phase to the next must be made visible for an automated analysis. Here we rely on a cell line from ChromoTek GmbH based on the Chromobody® technology, which was specifically developed for live cell imaging in high content drug research.
The Zeta software offers a simple and intuitive way to analyze complex processes during cell division. An easy-to-use interface guides the user through the complete analysis workflow. User interaction is required at important steps, in order to keep the analysis flexible and to let the user tailor the workflow to changing experimental requirements. One distinctive feature of Zeta is its plug-in architecture, which allows very flexible adaptation of the software. At program start a configuration file is used to load only those modules that are needed for the image analysis at hand. This modular architecture makes it easy to adapt Zeta to new analysis workflows.Contact:
Alex Deeg | Fraunhofer-Institut
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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