Under the agreement, toxicologists at Surrey will be using CCnet's unique ToxWiz software to assist their cutting edge research on drug and chemical safety. ToxWiz is a computer-based network of more than 2,500 annotated pathways and clusters linking genomics and proteomics data with biochemical pathways and cellular information
Professor Peter Goldfarb, director of the University's Centre for Toxicology, commented: "We will be using ToxWiz because it is one of the few software systems that can accurately explore the rapidly expanding knowledge base deriving both from prior research in toxicology and the current systems biology revolution. This will enable us to make earlier predictions about the safety of proposed new therapeutic agents and industrial chemicals.
Additionally, ToxWiz is designed to predict the possible cellular mechanisms of any indicated toxicity and should help us plan our subsequent experimental work better. This would result in a significant reduction in the use of test animals (an objective to which Surrey has contributed for many years) and also make the testing of such chemicals in man even safer. CCnet are clearly focused on novel solutions to the challenges facing toxicologists today, not only in terms of developing safe new treatments for diseases such as diabetes and cancer, but also in responding to the EU requirement for the retesting of chemicals to which the public are exposed in their everyday lives. We look forward to a productive collaboration."
Dr Mariana Vaschetto, Director of Cambridge Cell Networks commented: "Professor Goldfarb and his colleagues at the University of Surrey are leaders in the field of molecular toxicology and we are thrilled that they will be using ToxWiz to aid their cutting edge research. We are sure that their feedback will also be invaluable in helping us design the next generation of our software. With this contribution from an internationally recognised academic group, we will be able to target the continuing development of ToxWiz on meeting the increasingly rigorous needs of modern safety science."
Peter La | alfa
Stable magnetic bit of three atoms
21.09.2017 | Sonderforschungsbereich 668
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20.09.2017 | Universität Zürich
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
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