In this study the computational Biomechanics group lead by Fulvia Taddei at the Medical Technology Lab of the Rizzoli Orthopaedic Institute in Bologna, Italy, reports about an extensive validation study of the so-called subject-specific finite element analysis. This method makes possible the creation of computer models capable of predicting the mechanical stresses in any region of the skeleton of a given patient, starting only from a Computed Tomography exam of that subject.
In the study eight cadaver bones instrumented with dozen of sensors and subjected to multiple physiological loading conditions were used by the Experimental Biomechanics group lead by Luca Cristofolini to determine the mechanical stresses in the region of the proximal femur, consider one of the most difficult to model accurately.
Then the eight cadaver bones were examined with a standard clinical CT procedure; the eight computer models generated from these data were used to predict the mechanical stresses in the same loading conditions, and the predictions were then compared to the measured values. The study confirmed that the method developed at the Medical Technology Lab has accuracy better than 10%, which twice more accurate than any other previously published study.
This level of accuracy makes possible the introduction of these subject-specific predictive models in the clinical practice, in applications such as the prediction of the risk of fracture in osteoporotic patients, the preoperative planning of complex skeletal reconstructions in paediatric oncology or in traumatology, or the retrospective investigation of joint arthoplasties that failed in relation to biomechanical factors.
Annalisa Bandieri | alfa
Information integration and artificial intelligence for better diagnosis and therapy decisions
24.05.2017 | Fraunhofer MEVIS - Institut für Bildgestützte Medizin
World's thinnest hologram paves path to new 3-D world
18.05.2017 | RMIT University
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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23.05.2017 | Event News
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy