Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UC San Diego Supercomputer Simulations May Pinpoint Causes of Parkinson’s, Alzheimer’s Diseases

23.03.2007
Using the massive computer-simulation power of the San Diego Supercomputer Center (SDSC) at UC San Diego, researchers are zeroing in on the causes of Parkinson’s disease, Alzheimer’s disease, rheumatoid arthritis and other diseases.

A study published in this week’s Federation of European Biochemical Societies (FEBS) Journal offers – for the first time – a model for the complex process of aggregation of a protein known as alpha-synuclein, which in turn leads to harmful ring-like or pore-like structures in human membranes, the kind of damage found in Parkinson’s and Alzheimer’s patients.

The researchers at SDSC and UC San Diego also found that the destructive properties of alpha-synuclein can be blocked by beta-synuclein – a finding that could lead to treatments for many debilitating diseases.

The current journal’s cover features an image from the research that helps illustrate the scientists’ work.

“This is one of the first studies to use supercomputers to model how alpha-synuclein complexes damage the cells, and how that could be blocked,” said Eliezer Masliah, professor of neurosciences and pathology at UC San Diego. “We believe that these ring- or pore-like structures might be deleterious to the cells, and we have a unique opportunity to better understand how alpha-synuclein is involved in the pathogenesis of Parkinson’s disease, and how to reverse this process.”

Igor Tsigelny, project scientist in chemistry and biochemistry at UC San Diego and a researcher at SDSC, said that the team’s research helped confirm what researchers had suspected. “The present study – using molecular modeling and molecular dynamics simulations in combination with biochemical and ultrastructural analysis – shows that alpha-synuclein can lead to the formation of pore-like structures on membranes.”

In contrast, he said, “beta-synuclein appears to block the propagation of alpha-synucleins into harmful structures.”

The complex calculations for the study were performed on Blue Gene supercomputers at SDSC and the Argonne National Labs.

Tsigelny worked in collaboration with Pazit Bar-On, Department of Neurosciences; Yuriy Sharikov of SDSC; Leslie Crews of the Department of Pathology; Makoto Hashimoto of Neurosciences; Mark A. Miller of SDSC; Steve H. Keller in Medicine; Oleksandr Platoshyn and Jason X.J. Yuan, both in Medicine; and Masliah, all at UC San Diego.

The research was supported by funding from the National Institutes of Health, a Department of Energy INCITE Grant, the Argonne National Laboratory, and the SDSC/ IBM Institute for Innovation in Biomedical Simulations and Visualization

Media Contact: Paul K. Mueller, 858-534-8564

Paul K. Mueller | EurekAlert!
Further information:
http://www.ucsd.edu

More articles from Information Technology:

nachricht Snake-inspired robot uses kirigami to move
22.02.2018 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht Camera technology in vehicles: Low-latency image data compression
22.02.2018 | Fraunhofer-Institut für Nachrichtentechnik, Heinrich-Hertz-Institut, HHI

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>