To gain the greatest benefit from systems toxicology, scientists need to integrate toxicogenomic data with conventional toxicological end points. This integration enables a systematic search for clinically relevant molecular biomarkers that can be used to predict a compound’s toxicity profile, before expensive clinical trials are initiated.
ToxPedia supports a data driven approach to systems toxicology. The system enables biomarker identification based on an integrated analysis of toxicogenomic data, namely of high throughput transcriptomics, proteomics and metabolomics data, with conventional toxicological end points. The ToxPedia system is built on the well established Genedata Expressionist platform and has been expanded by Genedata’s professional services team in close collaboration with scientists from leading pharmaceutical organizations.
The system is designed to address the specific requirements of systems toxicology. Tight integration with all major high throughput technology platforms, coupled with sophisticated data quality assessment tools, enables ToxPedia to achieve the highest standards in data quality evaluation. Ultimately, the goal is that ToxPedia supports the standardization and automation of the entire systems toxicology workflow from the initial sample gathering stage through to final study reporting phases, and addresses compliancy aims such as 21 CFR Part 11 guidelines.
Genedata also collaborates actively with research consortia focused on biomarker discovery, including the consortia InnoMed, NewGeneris, and INCA.
tobe freeman | alfa
Japanese researchers develop ultrathin, highly elastic skin display
19.02.2018 | University of Tokyo
Why bees soared and slime flopped as inspirations for systems engineering
19.02.2018 | Georgia Institute of Technology
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
21.02.2018 | Life Sciences
21.02.2018 | Life Sciences
21.02.2018 | Materials Sciences