BaSysBio (Bacillus Systems Biology) will study the global regulation of gene transcription in the model bacterium Bacillus subtilis. This bacterium has significant economic potential as a producer of enzymes and metabolites, and is used in a wide range of industries, from pharmaceutical and chemical manufacturers to the agro and food sectors. Two disease-causing bacteria, Bacillus anthracis, responsible for Anthrax, and Staphylococcus aureus, responsible for secondary infections, are objects of research as well.
BaSysBio will provide new insight into the fundamental principles that control cellular processes. Subsequently, the initiative will contribute to the identification of new biomarkers, and innovative therapeutic targets for anti-bacterial drugs.
Genedata Phylosopher has been chosen as the central management and infrastructure solution for sharing and interpreting the experimental data generated within BaSysBio. The project will adapt an array of high-throughput genomics technologies, including transcriptomics, proteomics, metabolomics, fluxomics and cell reporter assays. As quantitative molecular profiling information is key for the development of predictive mathematical models, the Genedata Phylosopher tools will be used for integrating the BaSysBio data and interpreting it in its pathway context. “Thanks to Genedata we are able to pool the various partners’ genomics and systems biology expertise across the entire network,” BaSysBio project coordinator Dr. Philippe Noirot said.
For Genedata, anticipating the evolving needs of systems biology research is an important commitment and responsibility . The company currently supports several systems biology research consortia in Europe. Dr. Othmar Pfannes, CEO of Genedata AG, stated: “The project brings together the best teams in Europe, specialized in different fields from molecular biology to computational biology. We are proud to collaborate with this world class research consortium.”
tobe freeman | alfa
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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