High content data from cellular assay technologies used at Serono enable sophisticated biological profiling. These screening technologies provide insights into the biological effects of potential drug candidates, including possible toxic side effects.
To exploit these technologies, screening results need to be shared among people with different expertise, including chemists and toxicologists. Biopharmaceutical company Serono is familiar with this process, and is organized internally to ensure there is good communication between various expert groups.
To complement this process, Genedata’s result management and analysis solution Genedata Screener combines central database functions with interactive analysis tools and web-based access to databases. In step with recent developments in biomolecular screening, Genedata have developed a scientific platform to validate and analyze cellular assays.
During the course of the collaboration, Genedata extended its Screener solution, enabling Serono’s researchers to analyze and annotate their screening results more efficiently. The collaboration quickly reached the point where the software was a precise fit with Serono’s needs.
Scientists from Serono and Genedata co-authored a research presentation made at this year’s Society for Biomolecular Sciences annual meeting in Seattle, Washington. Genedata plays an important role in the exchange of knowledge at Serono, both internally and with the wider screening community.
The collaboration has progressed in stages since its initiation in 2003. In its current form, Genedata’s solution is compatible with Cellomics screening technologies and includes sophisticated Application Programming Interfaces (APIs), an important technology for web-based software applications.
Dr. Stephan Heyse, Head of Genedata Screener, explained, “We are very pleased with the way our solution has been adopted at Serono, not just within Serono’s IT department, but also in terms of integration with the company’s drug discovery processes”.
tobe freeman | alfa
Stable magnetic bit of three atoms
21.09.2017 | Sonderforschungsbereich 668
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20.09.2017 | Universität Zürich
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
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Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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