A computer-aided approach -- based on software-that-learns -- promises to provide a new tool that helps doctors tailor the dosage of abciximab, a medicine frequently used before angioplasty to lessen the chance of heart attack.
Dr. Mirna Urquidi-Macdonald, professor of engineering science and mechanics, says, "While we tried our approach first with abciximab, it may be applicable to other medicines that have a narrow therapeutical range between under dosing and overdosing."
The approach is described in the January issue of the journal, Clinical Pharmacology and Therapeutics. The authors are Urquidi-Macdonald, who worked on the project during a sabbatical at the National Institute on Aging, Gerontology Research Center in Baltimore, Md.; Dr. Donald E. Mager, National Institute on Aging, Gerontology Research Center, Baltimore, Md.; Dr. Mary A. Mascelli, Centocor Inc., Malvern, Pa.; Bart Frederick, Centocor, Inc., Malvern; Dr. Jane Freedman, Division of Cardiology, Boston University School of Medicine; Dr. Desmond J. Fitzgerald, The Royal College of Surgeons in Ireland; Dr. Neal S. Kleiman, Division of Cardiology, Baylor College of Medicine, Houston, Texas; and Dr. Darrell R. Abernethy, National Institute on Aging, Gerontology Research Center,.
Barbara Hale | EurekAlert!
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