Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New mathematical algorithms might help diagnose cancer

09.02.2004


Dartmouth researchers have developed an algorithm that might someday be used to analyze blood for diagnostic purposes. Using data from a mass spectrometer, a device that generates a molecular fingerprint of biological samples, the Dartmouth team’s calculations can distinguish healthy blood from diseased blood.



This study by Ryan Lilien, a Dartmouth M.D./Ph.D. student, Hany Farid, Assistant Professor of Computer Science , and Bruce Donald, the Foley Professor of Computer Science, appeared in the Journal of Computational Biology in December 2003.

"Our algorithm, named Q5, works on the assumption that the molecular composition of the blood changes between healthy and disease states," says Donald, the senior researcher on the project. "The goal of our work is to develop minimally invasive diagnostic methods with high predictive accuracy, and this is a promising first step."


Mathematical computations are routinely developed, varied and refined to analyze mass spectrometry data. Q5 uses mathematical techniques called Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) to differentiate between the mass spectra of healthy and diseased blood samples. Q5 learns with each sample it tests, resulting in better accuracy. The algorithm compares the molecular fingerprint of each sample to identify features that differ between the healthy and disease states.

"Our algorithm detected ovarian cancer with virtually 100% accuracy and prostate cancer with approximately 95% accuracy," explains Lilien, the lead author on the paper. "Q5 analyzes the mass spec data and offers control over the threshold between healthy and disease classification. Although we only tested against ovarian and prostate cancer, we think it’s possible that Q5 may be used to test for other cancers and diseases."

The researchers explain that there is much still to be learned from the different types of information within a sample of blood, and Q5 is one means of extracting new and important data.

"Most exciting to us, unlike previous mass spec disease diagnosis methods, Q5 provides clues about the molecular identities of abnormal proteins and peptides, which often cause disease. These altered proteins can serve as biomarkers, helping doctors make diagnosis and also helping researchers design better targeted drugs," says Donald.

This research is funded by the National Institutes of Health, the National Science Foundation, the John Simon Guggenheim Foundation, and an Alfred P. Sloan Fellowship.

Sue Knapp | Dartmouth College
Further information:
http://www.dartmouth.edu/~news/releases/2004/02/04.html

More articles from Information Technology:

nachricht Drones that drive
27.06.2017 | Massachusetts Institute of Technology, CSAIL

nachricht Ahead of the Curve
27.06.2017 | Institute of Science and Technology Austria

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>