Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Highly automated live cell imaging speeds up the search for new drugs

08.09.2014

Fraunhofer FIT will present the latest version of its Zeta Fluorescence Image Analysis software at MipTec, held in Basel, Switzerland, from September 23 to 25, 2014. Zeta, now extended to a software platform, supports the complete work process of finding new pharmaceutical agents. At MipTec, Fraunhofer FIT will demo advanced Zeta applications in cancer research and tissue analysis.

The new Zeta software platform allows researchers to implement specific imaging workflows for a broad range of applications in drug research very easily. The software was developed specifically for high content analysis of live cell imaging data that monitor and record the complete life cycle of cells.


Zeta's clean graphical user interface.

(c) Fraunhofer FIT

The particular challenge for image analysis here is to detect the different phases of cell modification and cell division, and to record their temporal relationship. On this basis, a special visualization tool makes it easy to explore the data, to find individual differences and to determine the causes for different reactions of the cells.

“Using Zeta, researchers can analyze complex processes in the division of cells very easily and intuitively. A simple user interface guides them through the entire analysis workflow. And due to the evolution of Zeta into a modular software platform, we can now implement new applications much faster and thus at lower cost for our clients”, Dr. Andreas Pippow, Fraunhofer Institute for Applied Information Technology FIT, points out the main advantages of the latest Zeta version.

New software interfaces in the new version make it easier to integrate Zeta into all-encompassing high content analysis workflows. Imaging software often exists only as an isolated application – which was true also for earlier Zeta versions. What users need, however, is full integration with image data management and statistical analyses. Only if all steps in the entire workflow are supported by one coherent system, the users can freely explore and exploit their data. The latest Zeta version is a significant step in this direction.

At MipTec, September 23 to 25, 2014, the Zeta developers from Fraunhofer FIT demo a Zeta application that determines the cell division rate in cell assays. It is currently being used in cancer research in a large German pharmaceutical company.

The FIT researchers also demo a Zeta application in the study of physiological functions in tissue samples. While both applications are used in the quest for new pharmaceutical agents, they apply completely different image analysis methods. In the first application, fluorescent markers identify the cells; in the second, the objects must be detected without any specific marking.

Contact:
Alex Deeg
pr@fit.fraunhofer.de
Phone +49 2241 14-2208

Alex Deeg | Fraunhofer-Institut
Further information:
http://www.fit.fraunhofer.de

Further reports about: FIT Zeta analyses analyze differences drugs identify individual markers methods special steps temporal

More articles from Information Technology:

nachricht New technology enables 5-D imaging in live animals, humans
16.01.2017 | University of Southern California

nachricht Fraunhofer FIT announces CloudTeams collaborative software development platform – join it for free
10.01.2017 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>