Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Highly automated live cell imaging speeds up the search for new drugs

08.09.2014

Fraunhofer FIT will present the latest version of its Zeta Fluorescence Image Analysis software at MipTec, held in Basel, Switzerland, from September 23 to 25, 2014. Zeta, now extended to a software platform, supports the complete work process of finding new pharmaceutical agents. At MipTec, Fraunhofer FIT will demo advanced Zeta applications in cancer research and tissue analysis.

The new Zeta software platform allows researchers to implement specific imaging workflows for a broad range of applications in drug research very easily. The software was developed specifically for high content analysis of live cell imaging data that monitor and record the complete life cycle of cells.


Zeta's clean graphical user interface.

(c) Fraunhofer FIT

The particular challenge for image analysis here is to detect the different phases of cell modification and cell division, and to record their temporal relationship. On this basis, a special visualization tool makes it easy to explore the data, to find individual differences and to determine the causes for different reactions of the cells.

“Using Zeta, researchers can analyze complex processes in the division of cells very easily and intuitively. A simple user interface guides them through the entire analysis workflow. And due to the evolution of Zeta into a modular software platform, we can now implement new applications much faster and thus at lower cost for our clients”, Dr. Andreas Pippow, Fraunhofer Institute for Applied Information Technology FIT, points out the main advantages of the latest Zeta version.

New software interfaces in the new version make it easier to integrate Zeta into all-encompassing high content analysis workflows. Imaging software often exists only as an isolated application – which was true also for earlier Zeta versions. What users need, however, is full integration with image data management and statistical analyses. Only if all steps in the entire workflow are supported by one coherent system, the users can freely explore and exploit their data. The latest Zeta version is a significant step in this direction.

At MipTec, September 23 to 25, 2014, the Zeta developers from Fraunhofer FIT demo a Zeta application that determines the cell division rate in cell assays. It is currently being used in cancer research in a large German pharmaceutical company.

The FIT researchers also demo a Zeta application in the study of physiological functions in tissue samples. While both applications are used in the quest for new pharmaceutical agents, they apply completely different image analysis methods. In the first application, fluorescent markers identify the cells; in the second, the objects must be detected without any specific marking.

Contact:
Alex Deeg
pr@fit.fraunhofer.de
Phone +49 2241 14-2208

Alex Deeg | Fraunhofer-Institut
Further information:
http://www.fit.fraunhofer.de

Further reports about: FIT Zeta analyses analyze differences drugs identify individual markers methods special steps temporal

More articles from Information Technology:

nachricht Defining the backbone of future mobile internet access
21.07.2017 | IHP - Leibniz-Institut für innovative Mikroelektronik

nachricht Researchers create new technique for manipulating polarization of terahertz radiation
20.07.2017 | Brown University

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>