Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Earlier diagnosis of diseases by automated biomolecular probing of cells, proteins and molecules

18.03.2010
Some 350 years ago, Prof. Robert Hooke was the first to identify individual plant cells through his microscope.

Ever since, microscopes have been indispensable tools for the life sciences; today, the most advanced are powerful enough to show pattern in individual molecules. On this level, Fraunhofer FIT offers complete turnkey systems for biomolecular analysis, diagnosis and screening in medical and pharmaceutical research. At HANNOVER MESSE our researchers present the latest generation of their devices and imaging analysis software.

Proteins, the cellular building blocks, can be visualized and analyzed in great detail today. Here, Fraunhofer FIT presents a fully automated high-performance microscope. One of its diagnostic applications will be to study the complex interactions of proteins between cells. In tumor diagnostics our microscope allows to classify slightly different types of tumors more precisely and to fine-tune therapy accordingly. Key factors for the superior performance of our system are high-precision hardware and image analysis software that is trainable and can be customized to the user's specific application.

The system produces a laser scan of a tissue probe's surface with a resolution of a few nanometers. In addition, the laser beam can trigger fluorescence effects that give more detailed insights into the morphology and structure of the probe. "The reflected light is used to compose high-resolution images of the probe; our learning, trainable image analysis software can extract more valuable information from these images than the tools widely used today," notes Dr. Harald Mathis, head of the department for Biomolecular Optical Systems at Fraunhofer FIT.

IMIKRID, the microfluidic diagnostic system, improves early diagnosis of cancer and cardiac diseases to make therapy more effective. IMIKRID is being developed by a group of Fraunhofer institutes led by Fraunhofer FIT. The system implements a novel detection method that can detect markers even at a single-molecule level of concentration. At its core is a microfluidic chip with four independent single-molecule biosensors.

Main application fields of IMIKRID are in cardiological preventive diagnostics to detect and monitor cardiac diseases, and in oncological diagnostics at very early, pre-symptom stages. A third field is lactate monitoring through sudor analysis, both in infarct prevention and in athletes' fitness monitoring.

IMIKRID and the automated protein-level microscope system will be presented at HANNOVER MESSE, Forum tech transfer - Gateway2Innovation in Hall 2, booth D12/E09, from April 19 to 23, 2010.

Alex Deeg | Fraunhofer Gesellschaft
Further information:
http://www.fit.fraunhofer.de

More articles from Information Technology:

nachricht Construction of practical quantum computers radically simplified
05.12.2016 | University of Sussex

nachricht UT professor develops algorithm to improve online mapping of disaster areas
29.11.2016 | University of Tennessee at Knoxville

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>