It enables pharmaceutical companies to Virtualise and Globalise their Research and Development (R&D) chain, lowering costs as well as considerably improving knowledge exchange between industrial and academic partners.
“One of the most important R&D strategies to achieve a significant gain of efficiency is to tap into external knowledge and expertise through a network of external alliances, sharing the risk, reward and control. Given the large investments in drug research, Virtualisation provides a great savings potential,” summarizes Professor Ulrich Trottenberg, director of Fraunhofer Institute for Algorithms and Scientific Computing SCAI, the SIMDAT project co-ordinator, the current challenges in pharmaceutical drug discovery.
“With the distributed nature and diverse location of biological data for disease and medical treatment, it is becoming vital to be able to fast and flexible connect to these resources. Grid as a key part of Information Technology supports the organisations’ rapid movement into the virtualised and now more globalised information market,” says Rob Gill, Head of Biology Domain Architecture at GSK. “The SIMDAT Grid technologies developed by GlaxoSmithKline (GSK), NEC, Inpharmatica (Galapagos), InforSense and Fraunhofer Institute for Algorithms and Scientific Computing SCAI provide a new business model in the life science sector, which can be considered as a success of the project as a whole.”
Usually, establishing new relationships by creating a new virtual organisation (VO) may take up to several months. But the “Data Grid” paradigm can reduce this to weeks or even days. The VO in this case demonstrates how a pharmaceutical company could partner with an academic group and a vendor company to look at a specific disease and drug target. The duration of this relationship depends on the questions asked and the costs incurred by the interaction. Biotech, on the other hand, has the opportunity to get access to new markets and, hence, is in the position to increase its commercial offer by implementing a finer grained product portfolio.
Knowledge exchange within SIMDAT is not bound to local infrastructure but is tending away from organisational, process and technology limitations. Thus, pharmaceutical companies like GSK have now the possibility to scale their business relationship with both biotech companies like Inpharmatica (Galapagos) and academic partners. That is, they can restrict themselves to exactly those resources they are interested in and are not forced to subscribe to a complete and costly product. This can be realised by new, grid-based middleware components, used to securely and transparently integrate distributed data repositories, in combination with distributed execution of process chains.
Through Virtualisation pharmaceutical companies like GSK are now capable of scaling their business relationship with both industrial and academic partners and take advantage of its great savings potential. In addition Globalisation is getting more and more crucial to keep up in an international context, especially considering the rate of growth of scientific and technical graduates in Asia is already outpacing the United States and Europe. Virtualisation has also the means to benefit from this wealth of knowledge along with developments in the global market.
Current industry applications can already take advantage of SIMDAT technologies. This was successfully demonstrated by a workflow-based test system implemented at GSK by InforSense, consisting of five different remote sites and including data services of two external companies. The development of this workflow is driven by the need to get high quality, state of the art analysis for pharmaceutical companies from wherever it is best sourced. Thus was shown that pharmaceutical R&D processes can be outsourced across multiple organizations, even if they are using different specifications. Thereby the central industrial requirement for a controlled and secure interaction has been fully addressed through internet security models provided by NEC.
As a powerful tool for knowledge exchange, SIMDAT technology broadens the scope of the drug discovery chain and is able to import the best of bread analysis from both academia and vendors at appropriate costs. It is an ideal showcase for potential providers who are interested in working with pharmaceutical partners in a more collaborative and beneficial manner rather than purely in a simple vendor consumer relationship.
SIMDAT has received research funding by the European Commission under the Information Society Technologies Programme (IST), contract number IST-2004-511438. Maximum Community contribution to project: 11 Mio Euro, Project start: 1 September 2004, Duration: 48 months, Partners involved: 27. The project is coordinated by the Fraunhofer Institute SCAI in Sankt Augustin, Germany.
Goodbye, login. Hello, heart scan
26.09.2017 | University at Buffalo
Stable magnetic bit of three atoms
21.09.2017 | Sonderforschungsbereich 668
Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.
Graphene is up to the job
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
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