Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Computational biologists assist global network of researcher teams in developing new medicines

28.02.2011
Many years can pass before a newly developed medicine can enter the market. Computational biologists in Saarbrücken and Tübingen would like to speed up this long and tedious process. They have developed the software BALLView, with which new active agents can be conceptualized and visualized. Now international research teams can meet on the web and work with three-dimensional molecular models together on their monitors.

Researchers from the Center for Bioinformatics in Saarbrücken will present a prototype of the new platform together with the Saarland University Intel Visual Computing Institute at the CeBIT 2011 in Hanover from March 1st through the 5th at the Saarland University research booth (hall 9, booth B43).

“If you are looking to find the right key for a lock, you have to be able to spatially visualize it. It is no different for researchers who need to comprehend the chemical and spatial forms and structures of molecules in order to develop new medicines,” Andreas Hildebrandt explains. He leads the research group at Saarland University that, together with computational biologists in Tübingen, has developed the freely available Software BALL (Biochemical ALgorithms Library), to which the visualization component BALLView has been added. With the help of BALLView, you can dive into the 3D virtual world of active agent molecules, DNA and viruses. This better spatial view makes it easier for the viewer to find the “key agent molecule” which geometrically and chemically fits the three-dimensional “lock”, the so-called receptor molecule, in the human body.

International research teams from different fields are working together closely from different sites to better understand these complex mechanisms. “Up to now, they could not work on the same three-dimensional models simultaneously because of limited network capacities and problems with data security, among other things,” the bioinformatician explains. For this reason, the research team in Saarbrücken is expanding its software by so-called collaborative functions. These enable researchers to do complex molecular modeling together on the Internet, simultaneously. The 3D technology needed for this was developed by Professor Philipp Slusallek and his research team from the Saarland University Intel Visual Computing Institute and the German Research Center for Artificial Intelligence (DFKI). The expansion of ordinary web browsers allows complex 3D graphics to be displayed.

“This new web technology was integrated into the BALLView software. And now researchers can also share and exchange their ideas directly in a chat window in BALLView,” Hildebrandt explains. The software works with a special visualization method called ray tracing which very realistically displays the spatial structures of molecules with lighting, shadows and reflections. It can be looked at with the help of a virtual reality setup or simply on a standard 3D television set. “Two images are superimposed, allowing the viewer to see them with enormous depth through 3D glasses and get an extremely realistic spatial impression. He can also move the proteins and viruses directly on the screen as well as zoom into and edit individual sections,” says Andreas Hildebrandt, who will soon take on a professorship at the university in Mainz. Visitors to the computer trade fair Cebit can give this new technology a try on a 3D television.

Press photos: www.uni-saarland.de/pressefotos

Contact:

Dr. Andreas Hildebrandt
E-Mail: anhi@bioinf.uni-sb.de
Friederike Meyer zu Tittingdorf
Tel. + 49 681 / 302-3610
Mobil + 49 151 / 11 37 16 32
Tel: + 49 511 / 89 49 70 22 (Cebit booth)
Information for radio journalists: If you would like to arrange a telephone interview with researchers and students from Saarland University in studio quality (Audio-ISDN-Codec), please contact Friederike Meyer zu Tittingdorf at the press office.

Saar - Uni - Presseteam | idw
Further information:
http://www.ballview.org

More articles from Information Technology:

nachricht UT professor develops algorithm to improve online mapping of disaster areas
29.11.2016 | University of Tennessee at Knoxville

nachricht New standard helps optical trackers follow moving objects precisely
23.11.2016 | National Institute of Standards and Technology (NIST)

All articles from Information Technology >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>