Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Reducing the risks of GM micro-organisms

09.12.2003


Scientists have developed a system to increase the safety of genetically modified (GM) microbes for release into the environment.



Release of GM micro-organisms is a cause of great concern to many, because the microbes could pass on genes for disease or other harmful traits to others. But, a team of researchers from Spain and Germany believes that it is possible to reduce this risk.

Dr. Eduardo Díaz of Centro de Investigaciones Biológicas-CSIC in Madrid and his colleagues have developed GM microbes that have containment systems based on different lethal functions.


“Lethal functions are any kind of molecule, usually proteins, that causes killing of the microbial cells,” explains Dr Díaz.

In the GM microbe, the lethal functions associated with the GM trait are not active. However, if this trait is transferred to a different microbe, the associated lethal functions become active and the recipient microbe dies (gene containment). Lethal functions can also be activated in the GM microbe upon completion of the biotechnological process by a specific signal from the environment, such as root exudates, temperature, or toxic pollutants (biological containment).

However, microbes can mutate, becoming resistant to the toxic effect of the lethal function. This leads to survival of a small fraction of the GM microbial population, which can multiply and then spread, uncontrolled. Avoiding the spread of potentially harmful traits is vital if GM microbes are to be used for our benefit.

Simply increasing the number of lethal functions helps to overcome this. “It is easier to inactivate one lethal function, than to inactivate two or more,” says Dr Díaz. However, this only works if the lethal functions (proteins) are different, if the functions act on different targets within the microbial cell, and if the functions are controlled separately. To become resistant to each individual lethal function would require numerous mutations.

Safe GM organisms would be of great benefit in applications where large amounts of microbes are needed, such as degrading pollutants on contaminated land, or for the development of live vaccines to prevent disease.

Faye Jones | alfa
Further information:
http://www.sgm.ac.uk

More articles from Ecology, The Environment and Conservation:

nachricht How does the loss of species alter ecosystems?
18.05.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Excess diesel emissions bring global health & environmental impacts
16.05.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Ecology, The Environment and Conservation >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

Information integration and artificial intelligence for better diagnosis and therapy decisions

24.05.2017 | Information Technology

CRTD receives 1.56 Mill. Euro BMBF-funding for retinal disease research

24.05.2017 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>