Investigations into coral disease, red tides and other marine environmental issues have led to discoveries of new chemicals as a source for pharmaceuticals. These chemicals function as antibiotics for microorganism providing survival advantages and may be usable in human health care.
Research by scientists from NOAA's National Ocean Service, The Medical University of South Carolina and North Carolina State University has found several compounds which exhibit very strong antibiotic, antifungal, and antiviral potential as well as some anti-cancer and angiogenesis activities. The research into coral disease has resulted in thousands of new bacterial isolates producing highly selective antimicrobial compounds yielding highly selective small peptide antibiotics.
Many of these novel antibiotics are advantageous, as they demonstrate no cytotoxic responses to human cells and may minimize negative side effects associated with those drugs in current usage. The researchers have yet to find a "known" resistant bacteria that cannot be made re-susceptible to current generation antibiotics, offering extended use of current drugs. We believe that one could apply many of these chemical mechanisms or novel pharmaceuticals to human disease resulting in a number of alternatives to deal with growing antibiotic resistance.
Observations from the sponge Agelas conifera's ability to protect itself against fouling and disease have led to the discovery of ageliferin derivatives that demonstrate very strong anti-biofilm activity. Compounds with this specific activity hold promise to increase the efficacy of current and out of use antibiotics because of their ability to inhibit and/or disperse the protective layer that infectious agents often produce to protect themselves. Such compounds are also finding potential use in other areas of human health as well, including cystic fibrosis, chemo-therapy, anti-fungal agents, and for use in medical stints and prosthetics.
Marine natural products hold much promise in combating both the trend of antibiotic resistance but also to discover new antibiotics. The one-two punch of discovering new antibiotics as well as novel chemicals that make older generation drugs more effective represents cutting edge science addressing a critical need in human health care.
Ben Sherman | EurekAlert!
Further reports about: > angiogenesis activities > anti-cancer activities > anti-fungal agents > antibiotic resistance > antibiotics > antifungal > antiviral potential > chemo-therapy > coral disease > cystic fibrosis > human health > marine environmental issues > medical stints > microorganism > novel ocean drugs > prosthetics > strong antibiotic
Successful calculation of human and natural influence on cloud formation
04.11.2016 | Goethe-Universität Frankfurt am Main
Invasive Insects Cost the World Billions Per Year
04.10.2016 | University of Adelaide
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Power and Electrical Engineering
05.12.2016 | Information Technology
05.12.2016 | Earth Sciences