Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs

16.02.2009
NOAA Science at AAAS

Investigations into coral disease, red tides and other marine environmental issues have led to discoveries of new chemicals as a source for pharmaceuticals. These chemicals function as antibiotics for microorganism providing survival advantages and may be usable in human health care.

Research by scientists from NOAA's National Ocean Service, The Medical University of South Carolina and North Carolina State University has found several compounds which exhibit very strong antibiotic, antifungal, and antiviral potential as well as some anti-cancer and angiogenesis activities. The research into coral disease has resulted in thousands of new bacterial isolates producing highly selective antimicrobial compounds yielding highly selective small peptide antibiotics.

Many of these novel antibiotics are advantageous, as they demonstrate no cytotoxic responses to human cells and may minimize negative side effects associated with those drugs in current usage. The researchers have yet to find a "known" resistant bacteria that cannot be made re-susceptible to current generation antibiotics, offering extended use of current drugs. We believe that one could apply many of these chemical mechanisms or novel pharmaceuticals to human disease resulting in a number of alternatives to deal with growing antibiotic resistance.

Observations from the sponge Agelas conifera's ability to protect itself against fouling and disease have led to the discovery of ageliferin derivatives that demonstrate very strong anti-biofilm activity. Compounds with this specific activity hold promise to increase the efficacy of current and out of use antibiotics because of their ability to inhibit and/or disperse the protective layer that infectious agents often produce to protect themselves. Such compounds are also finding potential use in other areas of human health as well, including cystic fibrosis, chemo-therapy, anti-fungal agents, and for use in medical stints and prosthetics.

Marine natural products hold much promise in combating both the trend of antibiotic resistance but also to discover new antibiotics. The one-two punch of discovering new antibiotics as well as novel chemicals that make older generation drugs more effective represents cutting edge science addressing a critical need in human health care.

Ben Sherman | EurekAlert!
Further information:
http://www.noaa.gov
http://www.hml.noaa.gov/ohh/ohhi/welcome.html
http://www.hml.noaa.gov/ohh/marineproducts/welcome.html

More articles from Ecology, The Environment and Conservation:

nachricht A new indicator for marine ecosystem changes: the diatom/dinoflagellate index
21.08.2017 | Leibniz-Institut für Ostseeforschung Warnemünde

nachricht Value from wastewater
16.08.2017 | Hochschule Landshut

All articles from Ecology, The Environment and Conservation >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Nagoya physicists resolve long-standing mystery of structure-less transition

21.08.2017 | Materials Sciences

Chronic stress induces fatal organ dysfunctions via a new neural circuit

21.08.2017 | Health and Medicine

Scientists from the MSU studied new liquid-crystalline photochrom

21.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>