Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New invention regulates nerve cells electronically

21.05.2010
A major step toward being able to regulate nerve cells externally with the help of electronics has been taken by researchers at Linköping University and the Karolinska Institute in Sweden. The breakthrough is based on an ion transistor of plastic that can transport ions and charged biomolecules and thereby address and regulate cells.

The invention, which opens new avenues for controlling chemical signals, is being published in the coming issue of the highly ranked scientific journal PNAS. The authors are Klas Tybrandt and Magnus Berggren of Linköping University, who developed the invention, and Karin Larsson and Agneta Richter-Dahlfors at the Karolinska Institute, who have used it in experiments with cultivated nerve cells.

The four scientists work at the OBOE Research Center, which is dedicated to the study and regulation of processes in living cells and tissue through the use of organic electronics.

Previously use has been made of nano-canals and nano-pores to actively control the concentration and transport of ions. But such components are difficult to produce and moreover function poorly when the salt content is high, which is a precondition in interaction with biological systems.

"To get around these problems, we exploited the similarity between ion-selective membranes - plastics that only conduct ions of one charge - and doped semiconductors, such as silicon. It was previously known that it is possible to produce diodes from such membranes. We took it a step further by joining two ion diodes into a transistor," says Klas Tybrandt, a doctoral candidate in organic electronics.

When an ion transistor was connected to cultivated nerve cells, it could be used to control the supply of the signal substance acetylcholin locally to the cells. The successful result demonstrates both that the component functions together with biological systems and that even tiny charged biomolecules can be transported without difficulty.

"Since the ion transistor is made of plastic, it can be integrated with other components we are developing. This means we can make use of inexpensive printing processes on flexible materials. We believe ion transistors will play a major role in various applications, such as the controlled delivery of drugs, lab-on-a-chip and sensors," says Magnus Berggren, Önnesjö professor of organic electronics.

Article: Ion bipolar junction transistors by Klas Tybrandt, Karin C. Larsson, Agneta Richter-Dahlfors, and Magnus Berggren, PNAS Ahead of print May 17 2010.

Contact: Klas Tybrandt phone: +46 (0)11-363334, mobile: +46 (0)70-4997772, klaty@itn.liu.se and Magnus Berggren phone: +46 (0)11-363637, mobile: +46 (0)709-783430, magbe@itn.liu.se

Pressofficer Åke Hjelm; åka.hjelm@liu.se; +46-13281 395

Åke Hjelm | idw
Further information:
http://www.oboe.nu/
http://www.pnas.org

More articles from Machine Engineering:

nachricht Nanostructured Alloying with Oxygen
09.04.2018 | Max-Planck-Institut für Eisenforschung GmbH

nachricht Enhanced ball screw drive with increased lifetime through novel double nut design
23.01.2018 | Technologie Lizenz-Büro (TLB) der Baden-Württembergischen Hochschulen GmbH

All articles from Machine Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>