Peptides could help chips
cling to nerve cells
Nerve cells soldered to semiconductors cross computing with neuroscience
Scientists in the United States are soldering nerve cells to semiconductors. Christine Schmidt and colleagues from the University of Texas at Austin use a sliver of protein to connect neurons and tiny crystals of semiconductors called quantum dots1.
This cross between biology and electronics could have useful applications, including the manufacture of prosthetics operated directly by a user’s nerve impulses, and sensors that detect tiny quantities of neurotoxins. It could also help to study how real brains work.
But it is hard to get a smooth dialogue going between neurons and semiconductors. Nerve cells tend to grow over every surface in sight, like lichen over stone, but they don’t stick very closely. The gap they leave produces a poor electrical contact.
Schmidt’s team creates specific, intimate links between neurons and semiconductors using a small protein fragment. One end of this peptide latches onto a nerve cell’s surface; the other sticks to the surface of the semiconductor. Being small, the peptide holds the two surfaces closely together.
One end of the peptide contains a chemical hook that snags a particular protein, called an integrin, that is present on the surface of human neurons. Peptides without this hook don’t attach to nerve cells. At the other end, a sulphur-containing chemical group bonds to the semiconductor cadmium sulphide.
Using these peptides, the researchers stud the surface of a neuron with tiny ’nanocrystals’ of cadmium sulphide, just three millionths of a millimetre (three nanometres) across. The nanocrystal-decorated cell is easy to see under the microscope because the crystals, also known as quantum dots, are fluorescent.
Quantum dots can act as miniature electronic devices, but the same approach could attach neurons to the larger semiconductor components of conventional microelectronic circuits. Another group at the University of Texas has devised peptides that recognize different kinds of semiconductor2., raising the possibility of peptide-solder molecules that are selective at both ends.
PHILIP BALL | © Nature News Service
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