Vijay Tiwari awarded prestigious grant to study how cancer cells transform to become invasive
Dr. Vijay Tiwari, a Group Leader at the Institute of Molecular Biology (IMB) at Johannes Gutenberg University Mainz, is one of only eleven Young Investigators to have been awarded a prestigious grant from the EpiGeneSys Network of Excellence this year. The €150,000 award incorporates Dr. Tiwari into a European-wide network of leading epigenetics scientists and will support his research into how cells from solid tumors become invasive.
A key feature in the progression of cancer is the transformation of benign solid tumors into malignant states that form metastases. Understanding how cells in a solid tumor acquire the ability to invade and colonize different parts of the body is key to developing new strategies to treat the disease. Dr. Vijay Tiwari will take a multidisciplinary approach involving genomics, molecular, systems, and computational biology to determine how epigenetic processes contribute to this transformation.
In particular, his group will study how signaling pathways acting on the chromatin influence the activity of genes and the transcriptional reprograming that occurs in cells when they obtain the properties required to leave a solid tumor. To do this, Dr. Tiwari’s group will develop novel approaches to provide important insights into a crucial stage of cancer progression. The award will therefore further strengthen IMB’s research at the interface between epigenetics and systems biology.
A further IMB Group Leader, Dr. Holger Richly, has been elected as Associate Member of the EpiGeneSys Network. Membership of this select group of internationally renowned scientists will support Dr. Richly in his research into molecular epigenetics and their involvement in the mechanisms underlying ageing and DNA repair. As members of the EpiGeneSys Network, the groups of Dr. Vijay Tiwari and Dr. Holger Richly will have full access to the Network’s activities, including their training program for students and postdocs.
Further information about Dr. Tiwari’s research can be found at www.imb-mainz.de/tiwari. The award is a Research Integrating Systems Biology and Epigenetics (RISE1) grant that makes Dr. Tiwari a member of the European Commission-funded EpiGeneSys Network of Excellence. Further information about the EpiGeneSys network can be found at www.epigenesys.eu/. For more information about Dr. Richly’s research please go to www.imb-mainz.de/richly.
The Institute of Molecular Biology gGmbH (IMB)
The Institute of Molecular Biology gGmbH (IMB) is a new center of excellence in the life sciences which was established in March 2011. Research at IMB concentrates on three cutting-edge areas: epigenetics, developmental biology, and DNA repair. The institute is a prime example of a successful collaboration between public authorities and a private foundation. The Boehringer Ingelheim Foundation has dedicated €100 million for a period of 10 years to cover the operating costs for research at IMB, while the state of Rhineland-Palatinate provided approximately €50 million for the construction of a state-of-the-art building. For more information about IMB please visit: www.imb-mainz.de.
The Boehringer Ingelheim Foundation
The Boehringer Ingelheim Foundation is an independent, non-profit organization committed to the promotion of the medical, biological, chemical, and pharmaceutical sciences. It was established in 1977 by Hubertus Liebrecht, a member of the shareholder family of the company Boehringer Ingelheim. In addition to various awards for up-and-coming scientists at Johannes Gutenberg University Mainz, the foundation has endowed €100 million over a period of ten years to finance the scientific running of the Institute of Molecular Biology (IMB) at Mainz University. For more information about the foundation and its programs, please visit www.boehringer-ingelheim-stiftung.de.
Petra Giegerich | idw
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...