UT Southwestern’s grants have come from the National Science Foundation (NSF) and the National Institutes of Health (NIH), which was allotted $10 billion to distribute through the Recovery Act. Additional grant applications from UT Southwestern are still pending.
The $42 million represents both direct costs – funds that go directly to the researcher – and indirect costs, which go to UT Southwestern to support institutional infrastructure. The total amount reflects funds received in fiscal 2009; many grants allow a two-year period to spend the funds.
As of early October, UT Southwestern faculty are principal investigators on 105 Recovery Act projects (104 through NIH, one through NSF), and two investigators had received Recovery Act funds by virtue of being subcontractors on grants awarded to other institutions. Dr. Perrie Adams, associate dean for research administration at UT Southwestern, said more grants probably will be awarded in the coming weeks and months.
“Even though the funding period for most of these grants is only two years, the hope is that their results ultimately will contribute significantly to patient care, in terms of new treatments or a better understanding of specific diseases,” Dr. Adams said. “This funding also allows investigators to gather data that will then allow them to pursue larger, longer-term grants. In addition, for some of our young investigators, getting their ideas funded at this level starts them on the path toward establishing themselves. It’s a major asset for leveraging in order to obtain future funding.”
The research grants support a wide range of laboratory and patient-centered studies aimed at improving the nation’s health, including projects focusing on cancer, heart disease, kidney disease, autism, neurodegenerative diseases and diabetes.
Some examples illustrate the anticipated impact of the grants:
• Dr. Joseph Hill, chief of cardiology, “Functional Genomics of Complex Vascular Disease,” $1,287,252. This grant will help expand research on the mechanisms of cardiovascular disease and includes support for a new, early-career faculty member. “More than 200 genetic associations with cardiovascular disease have been identified. Moving forward, we need to know how this information can be harnessed to predict who will develop heart disease and possibly develop new ways to intervene early in at-risk patients,” Dr. Hill said.
• Dr. Craig Powell, assistant professor of neurology and psychiatry, “Novel Genetic Animal Models of Autism,” $549,500. The goal of this project is to understand better the genetic causes of human autism by using genetically engineered animal models of the disease. “This approach can be used to identify novel therapies for patients with autism,” Dr. Powell said.
• Dr. Elizabeth Maher, associate professor of internal medicine and neurology, “Genotype and Metabolic Phenotype in Glioblastoma,” $1 million. Glioblastoma is the most common primary brain tumor and is considered one of the deadliest of human cancers. Dr. Maher and her colleagues in the Annette G. Strauss Center in Neuro-Oncology and in the Advanced Imaging Research Center focus on the metabolism of glioblastoma cells as a potential new target. “Our research will dissect the metabolic pathways that are abnormal in glioblastoma in a concerted effort to develop new therapies quickly,” Dr. Maher said. “We anticipate that our discoveries will be applicable to other cancers as well.”
Some of the Recovery Act grants awarded to UT Southwestern and other institutions fall under special priority categories designated by the NIH.
Grand Opportunities grants
Two UT Southwestern researchers received NIH Grand Opportunities grants, which support high-impact ideas that lend themselves to short-term funding and that might lay the foundation for new fields of investigation. Dr. Ellen Vitetta, director of the Cancer Immunobiology Center, was awarded $1,303,720 for research to develop a new vaccine for the hepatitis C virus, a major cause of liver cancer. Dr. Michael Roth, professor of biochemistry, received $3.75 million for a project that ultimately will produce a large database that researchers can use to design patient-specific, individualized therapies for lung cancer.
Ten of UT Southwestern’s Recovery Act grants are NIH Challenge Grants in Health and Science Research, a new initiative that focuses on specific knowledge gaps, scientific opportunities, new technologies, data generation or research methods that can benefit from an influx of funds to quickly advance disease-specific areas in significant ways. Dr. Maher’s grant falls into this category.Summer research experience for teachers and students
Dr. Perrie Adams -- www.utsouthwestern.edu/findfac/professional/0,2356,10035,00.html
Amanda Siegfried | Newswise Science News
BMBF funding for diabetes research on pancreas chip
08.02.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Helmholtz International Fellow Award for Sarah Amalia Teichmann
20.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences