For her discovery, Neta Pessah received one of the prestigious Kaye Innovation Awards presented on June 9 during the Hebrew University Board of Governors meeting in Jerusalem.
Epilepsy is one of the most common neurological disorders, affecting about one percent of the world's population. Many new antiepileptic drugs have been introduced to the clinics recently, but despite the availability of these drugs, about 30 percent of the patients are still not seizure free.
Furthermore, many of the available drugs cause side effects, which can sometimes be fatal. One of the leading drugs for treating epilepsy and other neurological disorders is valproic acid (VPA). However, this drug has two life threatening side effects, liver toxicity and fetal malformation, that are related to the drug's chemical structure.
In Pessah’s ongoing research with VPA, she was successful in designing and synthesizing a new family of compounds based on a non-harmful analogue of that drug. Two of the compounds she formulated, Alpha-F-TMCD and Alpha-Cl-TMCD, were found to be highly potent as anticonvulsants without harmful side effects when tested on animal models. Alpha-Cl-TMCD is now under further testing at the National Institutes of Health in the United States.
Pessah says that her results suggest that these two novel compounds have high potential for development into new drugs to treat different types of epilepsy, neuropathic pain and other central nervous system disorders. The compounds have shown high potency, wide safety margins and lack of harmful effects on fetuses.
The Kaye Innovation Awards have been given annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which will benefit the university and society.
Jerry Barach | Hebrew University
Changing the Energy Landscape: Affordable Electricity for All
20.10.2016 | Fraunhofer-Institut für Solare Energiesysteme ISE
Emmy Noether junior research group investigates new magnetic structures for spintronics applications
11.10.2016 | Johannes Gutenberg-Universität Mainz
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences