Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New method for successful bone tissue engineering wins Kaye Award for Hebrew U. researcher

23.06.2008
A new and better method for accelerating bone formation in cases of orthopedic injuries and conditions, such as osteoporosis, fractures and disc disorders, has been developed by Nadav Kimelman at the Hebrew University of Jerusalem's Faculty of Dental Medicine.

The method involves increasing oxygen availability in scaffolds in order to accelerate bone formation. The lack of such oxygen supply constitutes a serious impairment to successful tissue engineering.

For his work, Kimelman, who is a doctoral student under Prof. Dan Gazit, was chosen as one of the winners of a Kaye Innovation Award, which was presented on June 4 during the Hebrew University's 71st meeting of the Board of Governors.

The term 'tissue engineering' describes the development of biological replacements for damaged tissues or organs. Biological replacements could act as a solution for the shortage in organ donations and also serve as efficient substitutes for synthetic implants that usually fail in the long run.

For successful engineering of an organ or tissue, the appropriate cells, biological cues and a three-dimensional scaffold should be combined. This is also the case for bone tissue engineering in which cells, genes and scaffolds are combined to heal complex fractures that cannot be repaired otherwise.

One of the major hurdles in successful tissue engineering, however, is the lack of oxygen supply to the newly forming tissue – resulting in cell death and less efficient tissue formation.

Kimelman decided to overcome this fundamental hurdle by utilizing synthetic oxygen carriers as a way to increase oxygen availability in scaffolds. To validate their approach, they combined adult stem cells, programmed to generate bone tissue formation, with injectable scaffolds (hydrogels) containing synthetic oxygen carriers. They then tested the survival of the cells and the amount of bone that was generated.

The results demonstrated significant elevated bone formation and cell survival in the hydrogels supplemented with synthetic oxygen carriers compared to the control groups. They even found that the addition of oxygen carriers also led to more rapid bone formation than the controls.

His results show, for the first time, that synthetic oxygen carriers supplementation enhances and accelerates engineered bone formation, which he believes is achieved by elevating cell survival.

According to Kimelman, however, the results could pave the way for novel therapeutic strategies not only in orthopedics, but also in other medical applications such as cardiology and neurosurgery.

The Kaye Innovation Awards have been given annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which would benefit the university and society.

For further information, contact:

Rebecca Zeffert, Dept. of Media Relations, the Hebrew University, tel: 02-588-1641, cell: 054-882-0661

or Orit Sulitzeanu, Hebrew University spokesperson, tel: 02-5882910, cell: 054-882-0016.

Rebecca Zeffert | The Hebrew University of Jerusal
Further information:
http://media.huji.ac.il
http://www.huji.ac.il

More articles from Awards Funding:

nachricht The quest for the oldest ice on Earth
14.11.2016 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung

nachricht Empa Innovation Award for new flame retardant
09.11.2016 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>