Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Milan Fiala, MD, Receives 2008 Alzheimer Award Journal of Alzheimer’s Disease Annual Award for Outstanding Contribution

28.04.2008
Milan Fiala, MD, UCLA Orthopedic Hospital, has been chosen as the recipient of the 2008 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work, "Phagocytosis of amyloid-beta and inflammation: Two faces of innate immunity in Alzheimer’s disease" by M. Fiala, D.H. Cribbs, M. Rosenthal and G. Bernard (July 2007, JAD 11(4): 457-63). Each year the Associate Editors of the journal select an outstanding article from the previous year's volume for this prestigious award.

“I am very grateful for the recognition of our laboratory’s work by the Journal of Alzheimer’s Disease,” said Dr. Fiala. “This award belongs to all of my collaborators as well.”

Dr. Fiala’s work suggests that Alzheimer’s disease is a failure of the immune system to keep the brain clear from waste products of neuronal chemistries (the most important waste is called amyloid-beta, in particular “oligomeric” amyloid-beta in neurons). This concept of Alzheimer’s disease can be compared to uremia when kidneys fail to clear the uremic waste products of body chemistries. In the brain, clearance of waste is difficult because the transport mechanisms across the brain “firewall” (called the “blood-brain barrier”) are restricted. The immune cells have the ability to cross the firewall, clean amyloid-beta and protect neurons, but in patients with Alzheimer’s disease, these cells somehow lose the ability to keep neurons healthy. In fact, these immune cells may be over-doing the cleaning task and become inflamed, and then cause damage to the brain as they do to an inflamed joint. Fortunately, in parallel with these mechanistic discoveries, Dr. Fiala’s collaborative research is showing that the immune system of patients can be improved, at least in a test tube, using natural products, such as curcuminoids from turmeric. Therefore, Dr. Fiala is developing a blood test of immune deficiency (so-called “amyloid-beta stress test”) and new ways of immune treatment as an all-inclusive approach to Alzheimer’s disease detection and prevention.

“We hope that these discoveries will lead to an all-inclusive approach to Alzheimer’s disease — detection at an early stage and improvement of the immune system using immunostimulating therapies (e.g curcuminoids) or anti-inflammatory therapies (similar to those used in joint disorders) according to the state of the immune system.,” stated Dr. Fiala.

Dr. Fiala is a Research Professor of Orthopaedic Surgery at UCLA, Los Angeles, California. He received his initial training at the University of Charles IV, Prague, Czechoslovakia and his MD degree at the University of Geneva, Switzerland. He obtained a MSc (Epidemiology) from Harvard School of Public Health. He pursued translational research in respiratory, herpes and retroviruses viruses at the University of Washington, the University of Pennsylvania and UCLA, and his work played key role in controlling infections of immunocompromised patients.

In the last decade, Dr. Fiala has developed a modification of the amyloid-beta hypothesis suggesting that the underlying problem of Alzheimer’s disease patients lies in the defectiveness of the innate immune system to clear amyloid-beta in the brain. Dr. Fiala’s laboratory is situated in the Orthopaedic Hospital Research Center and includes key UCLA collaborators: John Adams, MD; Martin Hewison, PhD; Philip T. Liu, PhD; Araceli Espinosa-Jeffrey, PhD; Mark J. Rosenthal, MD; John M. Ringman, MD; and research staff including many gifted students. External collaborators include John Cashman, PhD, HBRI, San Diego; Naoyuki Taniguchi, Osaka University; and Albert S. Lossinsky, New Jersey Neuroscience Institute, Edison, New Jersey.

This annual award, generously sponsored by Elan Pharmaceuticals, will be presented to Dr. Fiala at the International Conference on Alzheimer’s Disease 2008 held in Chicago in July.

Astrid Engelen | alfa
Further information:
http://www.j-alz.com
http://www.iospress.nl

More articles from Awards Funding:

nachricht Otto Hahn Medal for Jaime Agudo-Canalejo
21.06.2017 | Max-Planck-Institut für Kolloid- und Grenzflächenforschung

nachricht Call for nominations of outstanding catalysis researchers for the Otto Roelen Medal 2018
20.06.2017 | DECHEMA Gesellschaft für Chemische Technik und Biotechnologie e.V.

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>