Forum for Science, Industry and Business

Milan Fiala, MD, Receives 2008 Alzheimer Award Journal of Alzheimer’s Disease Annual Award for Outstanding Contribution

“I am very grateful for the recognition of our laboratory’s work by the Journal of Alzheimer’s Disease,” said Dr. Fiala. “This award belongs to all of my collaborators as well.”

Dr. Fiala’s work suggests that Alzheimer’s disease is a failure of the immune system to keep the brain clear from waste products of neuronal chemistries (the most important waste is called amyloid-beta, in particular “oligomeric” amyloid-beta in neurons). This concept of Alzheimer’s disease can be compared to uremia when kidneys fail to clear the uremic waste products of body chemistries. In the brain, clearance of waste is difficult because the transport mechanisms across the brain “firewall” (called the “blood-brain barrier”) are restricted. The immune cells have the ability to cross the firewall, clean amyloid-beta and protect neurons, but in patients with Alzheimer’s disease, these cells somehow lose the ability to keep neurons healthy. In fact, these immune cells may be over-doing the cleaning task and become inflamed, and then cause damage to the brain as they do to an inflamed joint. Fortunately, in parallel with these mechanistic discoveries, Dr. Fiala’s collaborative research is showing that the immune system of patients can be improved, at least in a test tube, using natural products, such as curcuminoids from turmeric. Therefore, Dr. Fiala is developing a blood test of immune deficiency (so-called “amyloid-beta stress test”) and new ways of immune treatment as an all-inclusive approach to Alzheimer’s disease detection and prevention.

“We hope that these discoveries will lead to an all-inclusive approach to Alzheimer’s disease — detection at an early stage and improvement of the immune system using immunostimulating therapies (e.g curcuminoids) or anti-inflammatory therapies (similar to those used in joint disorders) according to the state of the immune system.,” stated Dr. Fiala.

Dr. Fiala is a Research Professor of Orthopaedic Surgery at UCLA, Los Angeles, California. He received his initial training at the University of Charles IV, Prague, Czechoslovakia and his MD degree at the University of Geneva, Switzerland. He obtained a MSc (Epidemiology) from Harvard School of Public Health. He pursued translational research in respiratory, herpes and retroviruses viruses at the University of Washington, the University of Pennsylvania and UCLA, and his work played key role in controlling infections of immunocompromised patients.

In the last decade, Dr. Fiala has developed a modification of the amyloid-beta hypothesis suggesting that the underlying problem of Alzheimer’s disease patients lies in the defectiveness of the innate immune system to clear amyloid-beta in the brain. Dr. Fiala’s laboratory is situated in the Orthopaedic Hospital Research Center and includes key UCLA collaborators: John Adams, MD; Martin Hewison, PhD; Philip T. Liu, PhD; Araceli Espinosa-Jeffrey, PhD; Mark J. Rosenthal, MD; John M. Ringman, MD; and research staff including many gifted students. External collaborators include John Cashman, PhD, HBRI, San Diego; Naoyuki Taniguchi, Osaka University; and Albert S. Lossinsky, New Jersey Neuroscience Institute, Edison, New Jersey.

This annual award, generously sponsored by Elan Pharmaceuticals, will be presented to Dr. Fiala at the International Conference on Alzheimer’s Disease 2008 held in Chicago in July.

Astrid Engelen | alfa
Further information:
http://www.j-alz.com
http://www.iospress.nl

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...