Once scientists have successfully decoded the molecular mechanisms of protein folding, new approaches for prevention, diagnosis and therapy could emerge. The Heinrich Wieland Prize 2011 will be awarded to Prof. F.-Ulrich Hartl, director at the MPI of Biochemistry in Martinsried, for his pioneering work in the field of protein folding. The award is sponsored by the Boehringer Ingelheim Foundation and comes with a prize money of 50,000 Euros.
The award ceremony will take place on 27 October 2011 from 02.00 – 04.00 p.m. in the Baeyer Auditorium of the LMU Munich (Faculty of Chemistry and Pharmacy, LMU Munich, Butenandtstr. 13, House F, Room FU 1,017, 81477 Munich). Journalists are cordially invited to join in the ceremony. Please register by e-mail to firstname.lastname@example.org.
Cells constantly produce thousands of different proteins involved in every bioprocess. Most proteins can only fulfill their biological functions – e.g. as enzymes in cell metabolism, antibodies in immune defense or structural proteins in the muscular system – when they adopt a defined, three-dimensional structure. Hartl’s pioneering work has changed our way of thinking of how proteins fold within cells. Contrary to the previously held view that all proteins fold spontaneously and of their own accord, the scientist developed a new concept – namely that protein folding is a complex process requiring the assistance of other proteins, known as chaperones.
Many chaperones belong to the stress or heat shock proteins. They not only facilitate the correct folding of newly synthesized proteins, but also step in during stress situations, for instance to repair any proteins that misfolded due to high temperatures. Furthermore, molecular chaperones now play an important role in biotechnology. Biotechnological companies use, for example, bacterial cells with an increased chaperone content to produce large amounts of active forms of proteins required for the production of drugs. The groundwork for this was provided, among other things, by one of Hartl’s discoveries – the “chaperonin”, a cylindrically formed molecule which folds proteins inside a protected chamber. In the past few years, Hartl has concentrated on the analysis of those neurodegenerative diseases that are characterized by the misfolding and aggregation of certain proteins.
“Professor Hartl’s research is a prime example of how basic research can find its way into biotechnological or medical application – in the long run, the results also have the potential to provide progress for the good of patients afflicted by such diseases”, declared Professor Dr. Konrad Sandhoff, chairman of the board of trustees of the Heinrich Wieland Prize.
Franz-Ulrich Hartl studied medicine and obtained his doctoral degree in Heidelberg in 1985. He then moved to the laboratory of Walter Neupert in Munich, where he first worked as a post-doc and then as a group leader. In 1991 he accepted a professorship in cell biology and genetics at Memorial Sloan-Kettering Cancer Center and Cornell Medical College in New York. He returned to Germany in 1997 to take up his present postion as director at the Max Planck Institute of Biochemistry in Martinsried, near Munich.
The international Heinrich Wieland Prize (HWP), which comes with a prize money of 50,000 Euros, honours outstanding research on biologically active molecules and systems and its clinical impact in the areas of chemistry, biochemistry and physiology. It is named after the German chemist and Nobel Prize winner Heinrich Otto Wieland (1877 – 1957), who was professor of chemistry in Munich for many years. The prize has been awarded annually by an independent board of trustees since 1964. The Boehringer Ingelheim Foundation assumed sponsorship of the prize in 2011. The Boehringer Ingelheim Foundation is an independent, non-profit-making foundation for the promotion of medical, biological, chemical and pharmaceutical research.Media contacts:
ERC: Six Advanced Grants for Helmholtz
10.04.2017 | Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren
German Federal Government Promotes Health Care Research
29.03.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences