The Michael J. Fox Foundation grant will be used to study the “Modulation of the CD40/CD40-Ligand neuroinflammatory pathway in Parkinson’s preclinical models.” This project could open a new avenue for therapeutic interventions in Parkinson’s disease, where current approaches are limited mainly to dopaminergic replacement therapies.
Dr. Djalil Coowar, AxoGlia’s CSO and Principal Investigator, and his colleague at LSCB, Dr. Manuel Buttini, expect that by blocking neuroinflammation through the disruption of the CD40-CD40L pathway, a neuroprotective, disease-modifying effect will be achieved.
“Modulating neuroinflammation in Parkinson’s disease could prove to be of therapeutic benefit and we are grateful to The Michael J. Fox Foundation for their support to our innovative strategies that identify neurorestorative and neuroprotective drug candidates,” said AxoGlia’s CEO Jean-Paul Scheuren.
About AxoGlia Therapeutics
Based in Luxembourg, AxoGlia is a pioneer in the development of small chemical entities having dual anti-neurodegenerative and anti-inflammatory capacities. These molecules act on two levels: the regeneration of nervous cells by influencing the cell fate / maturation of cellular precursors and modulating the activation of microglial cells. Our preclinical programs target compounds that enhance neurogenesis in the brain for endogenous neuronal replacement. The biological effects of these molecules hint towards pharmacological benefits in neuropathologies like Parkinson’s disease and Multiple Sclerosis.
About the LCSB
The Luxembourg Centre for Systems Biomedicine (LCSB) is an Interdisciplinary Research Centre established by the University of Luxembourg in 2009. The study of neurodegenerative diseases, especially Parkinson´s disease, is one of the major targets of the research activities at the LCSB. The objective is to apply systems-level approaches, by combining both experimental data and computational analysis, in order to gain insights into the molecular and cellular mechanisms of the disease that can help find new ways to diagnose and treat the disease.
About The Michael J. Fox Foundation
As the world’s largest private funder of Parkinson’s research, The Michael J. Fox Foundation is dedicated to accelerating a cure for Parkinson’s disease and improved therapies for those living with the condition today. The Foundation pursues its goals through an aggressively funded, highly targeted research program coupled with active global engagement of scientists, Parkinson’s patients, business leaders, clinical trial participants, donors and volunteers. In addition to funding more than $304 million in research to date, the Foundation has fundamentally altered the trajectory of progress toward a cure. Operating at the hub of worldwide Parkinson’s research, the Foundation forges groundbreaking collaborations with industry leaders, academic scientists and government research funders; increases the flow of participants into Parkinson’s disease clinical trials with its online tool, Fox Trial Finder; promotes Parkinson’s awareness through high-profile advocacy, events and outreach; and coordinates the grassroots involvement of thousands of Team Fox members around the world. Now through December 31, 2012, all new and increased giving to The Michael J. Fox Foundation, as well as gifts from donors who have not given since 2010 or earlier, will be matched on a dollar-for-dollar basis with the $50-million Brin Wojcicki Challenge, launched by Sergey Brin and Anne Wojcicki.
Extensive Funding for Research on Chromatin, Adrenal Gland, and Cancer Therapy
28.06.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Otto Hahn Medal for Jaime Agudo-Canalejo
21.06.2017 | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
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Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
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Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
28.06.2017 | Physics and Astronomy
28.06.2017 | Physics and Astronomy
28.06.2017 | Health and Medicine