Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MDC Researcher Zsuzsanna Izsvák Receives European Research Council Grant Worth EUR 1.94 Million

16.02.2012
Dr. Zsuzsanna Izsvák, research group leader at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, has been named recipient of a European Research Council (ERC Advanced) grant worth EUR 1.94 million for her research on “jumping genes” (transposons).

With the aid of the ERC grant, in the next five years she will focus on investigating how mobile DNA elements (transposons) influence the pathogenesis of cancer and other diseases in the human genome. Altogether, nine MDC researchers, including Dr. Izsvák, have received grants of more than one million euros from the ERC.

About half of the human genome consists of transposon-derived sequences. Active transposons can jump to various sites of the DNA, insert themselves into the genome of the host and continue to spread in this way. Due to this characteristic, transposons are also called “jumping genes”.

As a consequence of mutations, in the course of time most of these “jumping genes” in the human genome have lost their mobility; only a few are still active. These remnants of transposons were long considered to be without any function. However, latest studies have shown that transposons are by no means “junk DNA”, but rather can influence the regulation of genes.

“The human genome is much more complex than previously assumed. In many processes in the body and also in disease, transposons may be the decisive factor,” Dr. Izsvák said. “That is why we need to take a closer look at transposons and their influence.”

With the ERC grant, Dr. Izsvák wants to explore the influence of transposons under stress conditions that are triggered by environmental influences, such as toxins or heavy metals, and to understand the association between transposon-derived regulatory sequences and human diseases. Furthermore, together with her team, Dr. Izsvák wants to advance the use of artificially produced transposons for gene therapy.

Dr. Izsvák has worked for over twenty years in transposon research. After several years of research at the University of Minnesota in Minneapolis/USA and at the Netherlands Cancer Institute in Amsterdam, the Hungarian researcher joined the MDC in Berlin-Buch in 1999. She has headed the research group “Mobile DNA” since 2004. At an award ceremony in Stockholm that same year she received the European Young Investigator Award (EURYI), endowed with approximately one million euros, for her research on mobile genetic elements.

With Dr. Izsvák, altogether nine researchers in Berlin-Buch have been awarded one of the highly endowed ERC grants: Professor Gary Lewin, Professor Thomas Jentsch (Leibniz-Institut für Molekulare Pharmakologie, FMP/MDC), Professor Michael Gotthardt and Dr. Jan-Erik Siemens (all 2011), Dr. James Poulet, Dr. Matthew N. Poy and Professor Klaus Rajewsky (all 2010) and Dr. Francesca Spagnoli (2009).

Contact:
Barbara Bachtler
Press Department
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
in the Helmholtz Association
Robert-Rössle-Straße 10
13125 Berlin
Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | Max-Delbrück-Centrum
Further information:
http://www.mdc-berlin.de/

More articles from Awards Funding:

nachricht The quest for the oldest ice on Earth
14.11.2016 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung

nachricht Empa Innovation Award for new flame retardant
09.11.2016 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

IHP presents the fastest silicon-based transistor in the world

05.12.2016 | Power and Electrical Engineering

InLight study: insights into chemical processes using light

05.12.2016 | Materials Sciences

High-precision magnetic field sensing

05.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>