Professor Michael Bader and Professor Thomas Willnow have been awarded grants of a total of EUR 150,000 each over the next three years from the new funding program “Helmholtz International Research Groups”. The grants will be matched with the same amount from the respective cooperating countries.
Combating severe obesity is the goal of the joint research project of Professor Bader, Dr. Natalia Alenina (both MDC) and Professor João B. Pesquero (Universidade Federal de São Paulo, Brazil). To date, there has been no long-lasting, effective treatment for this serious health problem affecting 250 million people worldwide. As potential target for treatment, the researchers are currently focusing on the hormones of the tissue kallikrein-kinin system, which play an important role in muscle contraction, blood pressure regulation, blood clotting and pain sensation.
The Brazilian and German scientists recently showed that one of two receptors that transmit the effects of the tissue hormones is involved in the regulation of the hormone leptin that suppresses appetite. They showed that mice lacking the receptor B1 did not become fat despite a high-fat diet.
Increasingly, disorders of the metabolism are considered to be risk factors for neurodegenerative diseases. However, the molecular mechanisms that control metabolism and brain function and link them with each other are not adequately understood. The research group of Professor Willnow at the MDC has now identified a unique class of signaling receptors – the VPS10P receptors – that are involved both in neuronal survival processes in the brain (Alzheimer’s disease, frontotemporal lobar degeneration, bipolar disorder) and in the control of glucose and lipoprotein homeostasis in metabolic tissues (type 2 diabetes, atherosclerosis, hypercholesterolemia).
To better understand the function of VPS10P receptors in metabolism and in the brain, cardiovascular researchers at the MDC and neuroscientists of the MIND Center of Aarhus University (Denmark) are building up a new research program within the framework of the Helmholtz International Research Group “Metabolism and Neurodegeneration”. The coordinator is Dr. Vanessa Schmidt from the research group of Professor Willnow. She works closely with Dr. Mads Kjolby (research group of Prof. Anders Nykjaer, MIND, Lundbeck Foundation, Aarhus University, Denmark). The aim is to gain insights into the signaling crosstalk between the brain and peripheral tissues and to elucidate disease pathways common to metabolic disturbances and dementia.Contact:
Innovation Award of the United Nations Environment Programme for PhD Student from ZMT
22.03.2018 | Leibniz-Zentrum für Marine Tropenforschung (ZMT)
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19.03.2018 | INM - Leibniz-Institut für Neue Materialien gGmbH
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
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