Professor Michael Bader and Professor Thomas Willnow have been awarded grants of a total of EUR 150,000 each over the next three years from the new funding program “Helmholtz International Research Groups”. The grants will be matched with the same amount from the respective cooperating countries.
Combating severe obesity is the goal of the joint research project of Professor Bader, Dr. Natalia Alenina (both MDC) and Professor João B. Pesquero (Universidade Federal de São Paulo, Brazil). To date, there has been no long-lasting, effective treatment for this serious health problem affecting 250 million people worldwide. As potential target for treatment, the researchers are currently focusing on the hormones of the tissue kallikrein-kinin system, which play an important role in muscle contraction, blood pressure regulation, blood clotting and pain sensation.
The Brazilian and German scientists recently showed that one of two receptors that transmit the effects of the tissue hormones is involved in the regulation of the hormone leptin that suppresses appetite. They showed that mice lacking the receptor B1 did not become fat despite a high-fat diet.
Increasingly, disorders of the metabolism are considered to be risk factors for neurodegenerative diseases. However, the molecular mechanisms that control metabolism and brain function and link them with each other are not adequately understood. The research group of Professor Willnow at the MDC has now identified a unique class of signaling receptors – the VPS10P receptors – that are involved both in neuronal survival processes in the brain (Alzheimer’s disease, frontotemporal lobar degeneration, bipolar disorder) and in the control of glucose and lipoprotein homeostasis in metabolic tissues (type 2 diabetes, atherosclerosis, hypercholesterolemia).
To better understand the function of VPS10P receptors in metabolism and in the brain, cardiovascular researchers at the MDC and neuroscientists of the MIND Center of Aarhus University (Denmark) are building up a new research program within the framework of the Helmholtz International Research Group “Metabolism and Neurodegeneration”. The coordinator is Dr. Vanessa Schmidt from the research group of Professor Willnow. She works closely with Dr. Mads Kjolby (research group of Prof. Anders Nykjaer, MIND, Lundbeck Foundation, Aarhus University, Denmark). The aim is to gain insights into the signaling crosstalk between the brain and peripheral tissues and to elucidate disease pathways common to metabolic disturbances and dementia.Contact:
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31.01.2018 | Technische Universität Dresden
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A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
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23.02.2018 | Physics and Astronomy