Chemist Patrick Hrdlicka and molecular physiologist Madhu Papasani, who are both 32, were the youngest researchers chosen among several hundred applicants. They will be joined on the University of Idaho team by a senior scientist, growth biology Prof. Rod Hill.
The award is the first awarded to researchers in Idaho through the Exceptional, Unconventional Research Enabling Knowledge Acceleration or EUREKA program sponsored by the National Institutes of Health.
The $523,000 R-01 program grant over three years reflects the team’s approach as one that is exceptionally innovative and based on a novel approach that could have an extremely high impact on biomedical research conducted by the National Institutes of Health.
The Idaho team will explore new approaches to gene therapies by using locked nucleic acids or LNAs as invaders to target specific sections of chromosomes. The team will use zebrafish embryos in the study.
Their study will focus on ways to improve the targeting of the invader LNAs through chemical engineering and to show how they can affect the genes.
“We are very excited about having the support to explore this approach,” Papasani said. “We are proud to be recognized as one of the teams that proposed an idea considered both exceptional and unconventional.”
The researchers hope their work could help medical researchers speed the development of new drugs or lead to gene therapies that would be new approaches to treatment of diseases.
"We want to develop a chemical probe technology that binds more strongly to specific genetic sequences and can target many more sequences that is currently possible," Hrdlicka said. "If successful, this technology has the potential to treat diseases of genetic origin."About the University of Idaho
Bill Loftus | Newswise Science News
Breakthrough Prize for Kim Nasmyth
04.12.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH
The key to chemical transformations
29.11.2017 | Schweizerischer Nationalfonds SNF
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences